5KRA
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with DDT and DDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E, F (A, B, E, F) | Estrogen receptor | polymer | 257 | 29299.5 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D, G, H (C, D, G, H) | NCOA2 | polymer | 14 | 1666.9 | 4 | UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 3 | I, K (A, E) | 1-[2,2-bis(chloranyl)-1-(4-chlorophenyl)ethenyl]-4-chloranyl-benzene | non-polymer | 318.0 | 2 | Chemie (6WS) | |||
| 4 | J, L (B, F) | 1-chloranyl-4-[2,2,2-tris(chloranyl)-1-(4-chlorophenyl)ethyl]benzene | non-polymer | 354.5 | 2 | Chemie (6WT) | |||
| 5 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A, B, E, F: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 364 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 123865.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1345.0 | |
| All* | Total formula weight | 125210.9 |
