5KRA
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with DDT and DDE
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue 6WS A 601 |
| Chain | Residue |
| A | LEU346 |
| A | ALA350 |
| A | GLU353 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| A | ILE424 |
| A | PHE425 |
| A | LEU525 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 6WT B 601 |
| Chain | Residue |
| B | MET343 |
| B | LEU346 |
| B | ALA350 |
| B | GLU353 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | ILE424 |
| B | PHE425 |
| B | LEU428 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 6WS E 601 |
| Chain | Residue |
| E | LEU346 |
| E | ALA350 |
| E | GLU353 |
| E | ARG394 |
| E | MET421 |
| E | ILE424 |
| E | PHE425 |
| E | LEU525 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue 6WT F 601 |
| Chain | Residue |
| F | MET343 |
| F | LEU346 |
| F | ALA350 |
| F | GLU353 |
| F | ARG394 |
| F | PHE404 |
| F | MET421 |
| F | ILE424 |
| F | PHE425 |
| F | LEU525 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER699 | |
| D | SER699 | |
| G | SER699 | |
| H | SER699 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 176 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | ILE358-LEU378 | |
| A | ARG394-VAL418 | |
| B | ILE358-LEU378 | |
| B | ARG394-VAL418 | |
| E | ILE358-LEU378 | |
| E | ARG394-VAL418 | |
| F | ILE358-LEU378 | |
| F | ARG394-VAL418 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | TYR526 | |
| B | TYR526 | |
| E | TYR526 | |
| F | TYR526 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:7838153 |
| Chain | Residue | Details |
| A | ALA340 | |
| B | ALA340 | |
| E | ALA340 | |
| F | ALA340 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 |
| Chain | Residue | Details |
| A | SER433 | |
| B | SER433 | |
| E | SER433 | |
| F | SER433 |
