5KP5

Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CurD	polymer	443	49241.7	1	UniProt (F4Y432) Pfam (PF01154) Pfam (PF08540) In PDB	Moorea producens 3L	Hydroxymethylglutaryl-CoA synthase
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3		water	water		18.0	156	Chemie (HOH)

Sequence modifications

A: 1 - 419 (UniProt: F4Y432)

PDB	External Database	Details
Met -23	-	initiating methionine
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Ala 344	Lys 344	engineered mutation
Ala 345	Gln 345	engineered mutation
Ala 347	Gln 347	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49241.7
Non-Polymers*	Number of molecules	1
	Total formula weight	96.1
All*	Total formula weight	49337.7

*Water molecules are not included.