5KL4
Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with formylated DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Wilms tumor protein | polymer | 93 | 11292.9 | 2 | UniProt (P19544) Pfam (PF00096) | Homo sapiens (Human) | WT33 |
| 2 | B, E (B, E) | DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5FC)P*GP*T)-3') | polymer | 11 | 3458.2 | 2 | synthetic construct | ||
| 3 | C, F (C, F) | DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3') | polymer | 11 | 3293.2 | 2 | synthetic construct | ||
| 4 | G, H, I, L, M... (A, D) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 5 | J, O (A, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | K, P (A, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | Q (F) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | R, S, T, U, V... (A, B, C, D, E...) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A, D: 350 - 437 (UniProt: P19544)
| PDB | External Database | Details |
|---|---|---|
| Gly 345 | - | expression tag |
| Pro 346 | - | expression tag |
| Leu 347 | - | expression tag |
| Gly 348 | - | expression tag |
| Ser 349 | - | expression tag |
| His 369 | Gln 352 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 36088.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 619.7 | |
| All* | Total formula weight | 36708.4 |
