5KL4

Wilms Tumor Protein (WT1) ZnF2-4 Q369H in complex with formylated DNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS355
A	CYS360
A	HIS373
A	HIS377

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 502

Chain	Residue
A	CYS385
A	CYS388
A	HIS401
A	HIS405

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 503

Chain	Residue
A	CYS418
A	HIS431
A	HIS435
A	CYS413

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CA A 504

Chain	Residue
A	CYS355
A	CYS360
A	HOH627
A	HOH633

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	ARG390
A	HIS401
B	DG4

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	CYS355
D	CYS360
D	HIS373
D	HIS377

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN D 502

Chain	Residue
D	CYS385
D	CYS388
D	HIS401
D	HIS405

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN D 503

Chain	Residue
D	CYS413
D	CYS418
D	HIS431
D	HIS435

---

site_id	AC9
Number of Residues	5
Details	binding site for residue CA D 504

Chain	Residue
A	HOH646
D	CYS355
D	CYS360
D	HOH620
D	HOH626

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO D 505

Chain	Residue
D	ARG372
D	SER393
D	ARG394
E	DG6
E	HOH104

---

site_id	AD2
Number of Residues	1
Details	binding site for residue NA F 101

Chain	Residue
F	DC6

---

site_id	AD3
Number of Residues	12
Details	binding site for Di-nucleotide DG E 8 and 5FC E 9

Chain	Residue
D	LYS351
D	PHE364
D	HIS369
D	ARG372
E	DG7
E	DG10
E	HOH112
E	HOH116
E	HOH121
F	DG4
F	DC5
F	DC6

---

site_id	AD4
Number of Residues	11
Details	binding site for Di-nucleotide 5FC E 9 and DG E 10

Chain	Residue
D	LYS351
D	ARG366
D	HIS369
D	ARG372
E	DG8
E	DT11
E	HOH111
E	HOH112
F	DA2
F	5CM3
F	DG4

---

site_id	AD5
Number of Residues	10
Details	binding site for Di-nucleotide DA F 2 and 5CM F 3

Chain	Residue
D	ARG366
D	ASP368
E	DA1
E	DG10
E	DT11
F	DT1
F	DG4
F	HOH206
F	HOH207
F	HOH209

---

site_id	AD6
Number of Residues	9
Details	binding site for Di-nucleotide 5CM F 3 and DG F 4

Chain	Residue
D	ASP368
D	ARG372
D	LYS399
D	HOH616
E	DG8
E	5FC9
E	DG10
F	DA2
F	DC5

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CdfkdCerrFsrsdhlkrHqrr..H

Chain	Residue	Details
A	CYS355-HIS377
A	CYS385-HIS405
A	CYS413-HIS435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Zinc finger: {"description":"C2H2-type 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	44
Details	Region: {"description":"Important for interaction with target DNA"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Important for interaction with target DNA"}

Chain

Residue

Details

---