5KJZ
Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase type I-alpha regulatory subunit | polymer | 150 | 17086.7 | 1 | UniProt (P10644) Pfam (PF00027) | Homo sapiens (Human) | Tissue-specific extinguisher 1,TSE1 |
| 2 | B (A) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 1 | Chemie (PCG) | |||
| 3 | C, D (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | E (A) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 234 - 381 (UniProt: P10644)
| PDB | External Database | Details |
|---|---|---|
| Gly 232 | - | expression tag |
| Ser 233 | - | expression tag |
| Arg 316 | Gly 316 | engineered mutation |
| Thr 336 | Ala 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17086.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 529.4 | |
| All* | Total formula weight | 17616.1 |
