5KJZ
Co-crystal structure of PKA RI alpha CNB-B mutant (G316R/A336T) with cGMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase type I-alpha regulatory subunit | polymer | 150 | 17086.7 | 1 | UniProt (P10644) Pfam (PF00027) | Homo sapiens (Human) | Tissue-specific extinguisher 1,TSE1 |
| 2 | B (A) | CYCLIC GUANOSINE MONOPHOSPHATE | non-polymer | 345.2 | 1 | Chemie (PCG) PubChem (177270406) PubChem (136759845) PubChem (135398570) PubChem (135402012) PubChem (135415582) PubChem (135530416) PubChem (135566687) PubChem (135612771) PubChem (136122637) PubChem (136183234) PubChem (136183235) PubChem (136239427) PubChem (136268916) PubChem (136454903) PubChem (136454906) PubChem (136488083) PubChem (136488088) PubChem (136499047) PubChem (136678837) PubChem (137218937) PubChem (137234705) PubChem (137279777) PubChem (138399475) PubChem (164162904) | |||
| 3 | C, D (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 4 | E (A) | water | water | 18.0 | 236 | Chemie (HOH) |
Sequence modifications
A: 234 - 381 (UniProt: P10644)
| PDB | External Database | Details |
|---|---|---|
| Gly 232 | - | expression tag |
| Ser 233 | - | expression tag |
| Arg 316 | Gly 316 | engineered mutation |
| Thr 336 | Ala 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17086.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 529.4 | |
| All* | Total formula weight | 17616.1 |
