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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5KHU

Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AAnaphase-promoting complex subunit 1polymer1944217580.21UniProt (Q9H1A4)
Pfam (PF12859)
Pfam (PF20518)
Pfam (PF21282)
Pfam (PF18122)
In PDB		Homo sapiens (Human)APC1,Cyclosome subunit 1,Mitotic checkpoint regulator,Testis-specific gene 24 protein
2BAnaphase-promoting complex subunit 11polymer849854.61UniProt (Q9NYG5)
Pfam (PF12861)
In PDB		Homo sapiens (Human)APC11,Cyclosome subunit 11,Hepatocellular carcinoma-associated RING finger protein
3C, PCell division cycle protein 23 homologpolymer59769075.12UniProt (Q9UJX2)
Pfam (PF04049)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 8,APC8,Cyclosome subunit 8
4EAnaphase-promoting complex subunit 16polymer11011678.01UniProt (Q96DE5)
Pfam (PF17256)
In PDB		Homo sapiens (Human)APC16,Cyclosome subunit 16
5F, HCell division cycle protein 27 homologpolymer82492519.52UniProt (P30260)
Pfam (PF00515)
Pfam (PF12895)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 3,APC3,CDC27 homolog,CDC27Hs,H-NUC
6G, WAnaphase-promoting complex subunit CDC26polymer859920.12UniProt (Q8NHZ8)
Pfam (PF10471)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 12,APC12,Cell division cycle protein 26 homolog
7IAnaphase-promoting complex subunit 4polymer80892303.31UniProt (Q9UJX5)
Pfam (PF12894)
Pfam (PF12896)
In PDB		Homo sapiens (Human)APC4,Cyclosome subunit 4
8J, KCell division cycle protein 16 homologpolymer62071929.72UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)
In PDB		Homo sapiens (Human)Anaphase-promoting complex subunit 6,APC6,CDC16 homolog,CDC16Hs,Cyclosome subunit 6
9LAnaphase-promoting complex subunit 10polymer18521310.21UniProt (Q9UM13)
Pfam (PF03256)
In PDB		Homo sapiens (Human)APC10,Cyclosome subunit 10
10MAnaphase-promoting complex subunit 13polymer748528.31UniProt (Q9BS18)
Pfam (PF05839)
In PDB		Homo sapiens (Human)APC13,Cyclosome subunit 13
11NAnaphase-promoting complex subunit 2polymer82294149.21UniProt (Q9UJX6)
Pfam (PF00888)
Pfam (PF08672)
In PDB		Homo sapiens (Human)APC2,Cyclosome subunit 2
12OAnaphase-promoting complex subunit 5polymer75585446.01UniProt (Q9UJX4)
Pfam (PF21371)
Pfam (PF12862)
In PDB		Homo sapiens (Human)APC5,Cyclosome subunit 5
13QMitotic checkpoint serine/threonine-protein kinase BUB1 betapolymer1050120004.21UniProt (O60566)
Pfam (PF08311)
In PDB		Homo sapiens (Human)MAD3/BUB1-related protein kinase,hBUBR1,Mitotic checkpoint kinase MAD3L,Protein SSK1
14R, SCell division cycle protein 20 homologpolymer49954796.52UniProt (Q12834)
Pfam (PF12894)
Pfam (PF00400)
In PDB		Homo sapiens (Human)p55CDC
15TMitotic spindle assembly checkpoint protein MAD2Apolymer20523533.91UniProt (Q13257)
Pfam (PF02301)
In PDB		Homo sapiens (Human)HsMAD2,Mitotic arrest deficient 2-like protein 1,MAD2-like protein 1
16Uunknownpolymer9785.91Homo sapiens (Human)
17X, YAnaphase-promoting complex subunit 7polymer56563386.22UniProt (Q9UJX3)
Pfam (PF13181)
In PDB		Homo sapiens (Human)APC7,Cyclosome subunit 7
Sequence modifications
A: 1 - 1944 (UniProt: Q9H1A4)
PDBExternal DatabaseDetails
Glu 202Ser 202engineered mutation
Glu 286Ser 286engineered mutation
Glu 291Thr 291engineered mutation
Glu 313Ser 313engineered mutation
Glu 316Thr 316engineered mutation
Glu 317Ser 317engineered mutation
Glu 334Ser 334engineered mutation
Glu 341Ser 341engineered mutation
Glu 343Ser 343engineered mutation
Glu 355Ser 355engineered mutation
Glu 362Ser 362engineered mutation
Glu 372Ser 372engineered mutation
Glu 377Ser 377engineered mutation
GluThr 537engineered mutation
GluSer 547engineered mutation
GluSer 555engineered mutation
GluSer 569engineered mutation
Gln 671Asn 671conflict
GluSer 688engineered mutation
GluSer 699engineered mutation
Glu 916Ser 916engineered mutation
Glu 1347Ser 1347engineered mutation
C, P: 1 - 597 (UniProt: Q9UJX2)
PDBExternal DatabaseDetails
Glu 542Thr 542engineered mutation
Glu 562Thr 562engineered mutation
Glu 582Thr 582engineered mutation
Glu 588Ser 588engineered mutation
Glu 596Thr 596engineered mutation
F, H: 1 - 824 (UniProt: P30260)
PDBExternal DatabaseDetails
Glu 200Thr 200engineered mutation
Glu 205Thr 205engineered mutation
Glu 220Ser 220engineered mutation
Glu 241Ser 241engineered mutation
Glu 276Ser 276engineered mutation
Glu 320Ser 320engineered mutation
Glu 336Ser 336engineered mutation
Glu 339Ser 339engineered mutation
Glu 386Ser 386engineered mutation
Glu 387Ser 387engineered mutation
Glu 393Ser 393engineered mutation
Glu 426Ser 426engineered mutation
Glu 435Ser 435engineered mutation
Glu 446Thr 446engineered mutation
G, W: 1 - 85 (UniProt: Q8NHZ8)
PDBExternal DatabaseDetails
Glu 51Ser 51engineered mutation
Glu 52Ser 52engineered mutation
Glu 82Ser 82engineered mutation
I: 1 - 808 (UniProt: Q9UJX5)
PDBExternal DatabaseDetails
Glu 777Ser 777engineered mutation
Glu 779Ser 779engineered mutation
J, K: 1 - 620 (UniProt: Q13042)
PDBExternal DatabaseDetails
Glu 112Ser 112engineered mutation
Glu 560Ser 560engineered mutation
Glu 581Thr 581engineered mutation
Glu 585Thr 585engineered mutation
Glu 586Ser 586engineered mutation
L: 1 - 184 (UniProt: Q9UM13)
PDBExternal DatabaseDetails
Glu 3Thr 3engineered mutation
N: 1 - 822 (UniProt: Q9UJX6)
PDBExternal DatabaseDetails
Glu 218Ser 218engineered mutation
Glu 314Ser 314engineered mutation
Glu 470Ser 470engineered mutation
Glu 534Ser 534engineered mutation
Glu 811Ser 811engineered mutation
O: 1 - 755 (UniProt: Q9UJX4)
PDBExternal DatabaseDetails
Glu 178Thr 178engineered mutation
Glu 179Ser 179engineered mutation
Glu 195Ser 195engineered mutation
Glu 202Ser 202engineered mutation
Glu 221Ser 221engineered mutation
Glu 232Thr 232engineered mutation
Glu 364Ser 364engineered mutation
Q: 1 - 1050 (UniProt: O60566)
PDBExternal DatabaseDetails
Glu 367Ser 367engineered mutation
Glu 435Ser 435engineered mutation
Glu 543Ser 543engineered mutation
Glu 600Thr 600engineered mutation
Glu 665Ser 665engineered mutation
Glu 670Ser 670engineered mutation
Glu 720Ser 720engineered mutation
Glu 1043Ser 1043engineered mutation
X, Y: 35 - 599 (UniProt: Q9UJX3)
PDBExternal DatabaseDetails
Glu 119Ser 119engineered mutation
Glu 120Thr 120engineered mutation
Glu 123Ser 123engineered mutation
Glu 125Ser 125engineered mutation
Glu 126Thr 126engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains23
Total formula weight1408427.9
All*Total formula weight1408427.9
*Water molecules are not included.

219140

PDB entries from 2024-05-01

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