5KHU

Model of human Anaphase-promoting complex/Cyclosome (APC15 deletion mutant), in complex with the Mitotic checkpoint complex (APC/C-CDC20-MCC) based on cryo EM data at 4.8 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005680	cellular_component	anaphase-promoting complex
A	0005829	cellular_component	cytosol
A	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016567	biological_process	protein ubiquitination
A	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
A	0051301	biological_process	cell division
A	0051445	biological_process	regulation of meiotic cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0070979	biological_process	protein K11-linked ubiquitination
B	0000278	biological_process	mitotic cell cycle
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005680	cellular_component	anaphase-promoting complex
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
B	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
B	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
B	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0051445	biological_process	regulation of meiotic cell cycle
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0097602	molecular_function	cullin family protein binding
C	0000278	biological_process	mitotic cell cycle
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005680	cellular_component	anaphase-promoting complex
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007080	biological_process	mitotic metaphase chromosome alignment
C	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
C	0007096	biological_process	regulation of exit from mitosis
C	0007346	biological_process	regulation of mitotic cell cycle
C	0016567	biological_process	protein ubiquitination
C	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
C	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
C	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
C	0051301	biological_process	cell division
C	0051445	biological_process	regulation of meiotic cell cycle
C	0070936	biological_process	protein K48-linked ubiquitination
C	0070979	biological_process	protein K11-linked ubiquitination
E	0000775	cellular_component	chromosome, centromeric region
E	0000776	cellular_component	kinetochore
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005680	cellular_component	anaphase-promoting complex
E	0005694	cellular_component	chromosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007346	biological_process	regulation of mitotic cell cycle
E	0016567	biological_process	protein ubiquitination
E	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
E	0051301	biological_process	cell division
E	0051445	biological_process	regulation of meiotic cell cycle
E	0070936	biological_process	protein K48-linked ubiquitination
E	0070979	biological_process	protein K11-linked ubiquitination
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005680	cellular_component	anaphase-promoting complex
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
F	0007346	biological_process	regulation of mitotic cell cycle
F	0016567	biological_process	protein ubiquitination
F	0019903	molecular_function	protein phosphatase binding
F	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
F	0051301	biological_process	cell division
F	0051445	biological_process	regulation of meiotic cell cycle
F	0070936	biological_process	protein K48-linked ubiquitination
F	0070979	biological_process	protein K11-linked ubiquitination
F	0072686	cellular_component	mitotic spindle
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005680	cellular_component	anaphase-promoting complex
G	0005829	cellular_component	cytosol
G	0007346	biological_process	regulation of mitotic cell cycle
G	0016567	biological_process	protein ubiquitination
G	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
G	0051301	biological_process	cell division
G	0051445	biological_process	regulation of meiotic cell cycle
G	0070936	biological_process	protein K48-linked ubiquitination
G	0070979	biological_process	protein K11-linked ubiquitination
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005680	cellular_component	anaphase-promoting complex
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
H	0007346	biological_process	regulation of mitotic cell cycle
H	0016567	biological_process	protein ubiquitination
H	0019903	molecular_function	protein phosphatase binding
H	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
H	0051301	biological_process	cell division
H	0051445	biological_process	regulation of meiotic cell cycle
H	0070936	biological_process	protein K48-linked ubiquitination
H	0070979	biological_process	protein K11-linked ubiquitination
H	0072686	cellular_component	mitotic spindle
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005680	cellular_component	anaphase-promoting complex
I	0005829	cellular_component	cytosol
I	0007346	biological_process	regulation of mitotic cell cycle
I	0016567	biological_process	protein ubiquitination
I	0019903	molecular_function	protein phosphatase binding
I	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
I	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
I	0034399	cellular_component	nuclear periphery
I	0051301	biological_process	cell division
I	0051445	biological_process	regulation of meiotic cell cycle
I	0070936	biological_process	protein K48-linked ubiquitination
I	0070979	biological_process	protein K11-linked ubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005680	cellular_component	anaphase-promoting complex
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0007346	biological_process	regulation of mitotic cell cycle
J	0016567	biological_process	protein ubiquitination
J	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
J	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
J	0051301	biological_process	cell division
J	0051445	biological_process	regulation of meiotic cell cycle
J	0070936	biological_process	protein K48-linked ubiquitination
J	0070979	biological_process	protein K11-linked ubiquitination
J	0072686	cellular_component	mitotic spindle
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005680	cellular_component	anaphase-promoting complex
K	0005737	cellular_component	cytoplasm
K	0005813	cellular_component	centrosome
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0007346	biological_process	regulation of mitotic cell cycle
K	0016567	biological_process	protein ubiquitination
K	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
K	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
K	0051301	biological_process	cell division
K	0051445	biological_process	regulation of meiotic cell cycle
K	0070936	biological_process	protein K48-linked ubiquitination
K	0070979	biological_process	protein K11-linked ubiquitination
K	0072686	cellular_component	mitotic spindle
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005680	cellular_component	anaphase-promoting complex
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0007346	biological_process	regulation of mitotic cell cycle
L	0016567	biological_process	protein ubiquitination
L	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
L	0051301	biological_process	cell division
L	0051445	biological_process	regulation of meiotic cell cycle
L	0070936	biological_process	protein K48-linked ubiquitination
L	0070979	biological_process	protein K11-linked ubiquitination
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005680	cellular_component	anaphase-promoting complex
M	0007346	biological_process	regulation of mitotic cell cycle
M	0016567	biological_process	protein ubiquitination
M	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
M	0051301	biological_process	cell division
M	0051445	biological_process	regulation of meiotic cell cycle
M	0070936	biological_process	protein K48-linked ubiquitination
M	0070979	biological_process	protein K11-linked ubiquitination
N	0005515	molecular_function	protein binding
N	0005654	cellular_component	nucleoplasm
N	0005680	cellular_component	anaphase-promoting complex
N	0005829	cellular_component	cytosol
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
N	0007346	biological_process	regulation of mitotic cell cycle
N	0007399	biological_process	nervous system development
N	0010629	biological_process	negative regulation of gene expression
N	0016567	biological_process	protein ubiquitination
N	0030154	biological_process	cell differentiation
N	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
N	0031461	cellular_component	cullin-RING ubiquitin ligase complex
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0031915	biological_process	positive regulation of synaptic plasticity
N	0045773	biological_process	positive regulation of axon extension
N	0050775	biological_process	positive regulation of dendrite morphogenesis
N	0051301	biological_process	cell division
N	0051445	biological_process	regulation of meiotic cell cycle
N	0070936	biological_process	protein K48-linked ubiquitination
N	0070979	biological_process	protein K11-linked ubiquitination
N	0090129	biological_process	positive regulation of synapse maturation
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005680	cellular_component	anaphase-promoting complex
O	0005737	cellular_component	cytoplasm
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0007346	biological_process	regulation of mitotic cell cycle
O	0016567	biological_process	protein ubiquitination
O	0019903	molecular_function	protein phosphatase binding
O	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
O	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
O	0051301	biological_process	cell division
O	0051445	biological_process	regulation of meiotic cell cycle
O	0070936	biological_process	protein K48-linked ubiquitination
O	0070979	biological_process	protein K11-linked ubiquitination
P	0000278	biological_process	mitotic cell cycle
P	0004842	molecular_function	ubiquitin-protein transferase activity
P	0005515	molecular_function	protein binding
P	0005654	cellular_component	nucleoplasm
P	0005680	cellular_component	anaphase-promoting complex
P	0005829	cellular_component	cytosol
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0007080	biological_process	mitotic metaphase chromosome alignment
P	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
P	0007096	biological_process	regulation of exit from mitosis
P	0007346	biological_process	regulation of mitotic cell cycle
P	0016567	biological_process	protein ubiquitination
P	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
P	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
P	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
P	0051301	biological_process	cell division
P	0051445	biological_process	regulation of meiotic cell cycle
P	0070936	biological_process	protein K48-linked ubiquitination
P	0070979	biological_process	protein K11-linked ubiquitination
Q	0000775	cellular_component	chromosome, centromeric region
Q	0000776	cellular_component	kinetochore
Q	0000940	cellular_component	outer kinetochore
Q	0004672	molecular_function	protein kinase activity
Q	0004674	molecular_function	protein serine/threonine kinase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005680	cellular_component	anaphase-promoting complex
Q	0005694	cellular_component	chromosome
Q	0005737	cellular_component	cytoplasm
Q	0005813	cellular_component	centrosome
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0006915	biological_process	apoptotic process
Q	0007091	biological_process	metaphase/anaphase transition of mitotic cell cycle
Q	0007094	biological_process	mitotic spindle assembly checkpoint signaling
Q	0033597	cellular_component	mitotic checkpoint complex
Q	0048471	cellular_component	perinuclear region of cytoplasm
Q	0051301	biological_process	cell division
Q	0051754	biological_process	meiotic sister chromatid cohesion, centromeric
Q	0071459	biological_process	protein localization to chromosome, centromeric region
Q	0106310	molecular_function	protein serine kinase activity
R	0000775	cellular_component	chromosome, centromeric region
R	0000776	cellular_component	kinetochore
R	0000922	cellular_component	spindle pole
R	0005515	molecular_function	protein binding
R	0005654	cellular_component	nucleoplasm
R	0005680	cellular_component	anaphase-promoting complex
R	0005694	cellular_component	chromosome
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005819	cellular_component	spindle
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0007064	biological_process	mitotic sister chromatid cohesion
R	0007094	biological_process	mitotic spindle assembly checkpoint signaling
R	0007346	biological_process	regulation of mitotic cell cycle
R	0007399	biological_process	nervous system development
R	0010997	molecular_function	anaphase-promoting complex binding
R	0016567	biological_process	protein ubiquitination
R	0030154	biological_process	cell differentiation
R	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
R	0031915	biological_process	positive regulation of synaptic plasticity
R	0033597	cellular_component	mitotic checkpoint complex
R	0040020	biological_process	regulation of meiotic nuclear division
R	0044784	biological_process	metaphase/anaphase transition of cell cycle
R	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
R	0051301	biological_process	cell division
R	0051445	biological_process	regulation of meiotic cell cycle
R	0090129	biological_process	positive regulation of synapse maturation
R	0090307	biological_process	mitotic spindle assembly
R	0097027	molecular_function	ubiquitin-protein transferase activator activity
R	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
R	1905786	biological_process	positive regulation of anaphase-promoting complex-dependent catabolic process
R	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
R	1990757	molecular_function	ubiquitin ligase activator activity
R	1990949	biological_process	metaphase/anaphase transition of meiosis I
S	0000775	cellular_component	chromosome, centromeric region
S	0000776	cellular_component	kinetochore
S	0000922	cellular_component	spindle pole
S	0005515	molecular_function	protein binding
S	0005654	cellular_component	nucleoplasm
S	0005680	cellular_component	anaphase-promoting complex
S	0005694	cellular_component	chromosome
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0007064	biological_process	mitotic sister chromatid cohesion
S	0007094	biological_process	mitotic spindle assembly checkpoint signaling
S	0007346	biological_process	regulation of mitotic cell cycle
S	0007399	biological_process	nervous system development
S	0010997	molecular_function	anaphase-promoting complex binding
S	0016567	biological_process	protein ubiquitination
S	0030154	biological_process	cell differentiation
S	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
S	0031915	biological_process	positive regulation of synaptic plasticity
S	0033597	cellular_component	mitotic checkpoint complex
S	0040020	biological_process	regulation of meiotic nuclear division
S	0044784	biological_process	metaphase/anaphase transition of cell cycle
S	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
S	0051301	biological_process	cell division
S	0051445	biological_process	regulation of meiotic cell cycle
S	0090129	biological_process	positive regulation of synapse maturation
S	0090307	biological_process	mitotic spindle assembly
S	0097027	molecular_function	ubiquitin-protein transferase activator activity
S	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
S	1905786	biological_process	positive regulation of anaphase-promoting complex-dependent catabolic process
S	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
S	1990757	molecular_function	ubiquitin ligase activator activity
S	1990949	biological_process	metaphase/anaphase transition of meiosis I
T	0000070	biological_process	mitotic sister chromatid segregation
T	0000132	biological_process	establishment of mitotic spindle orientation
T	0000775	cellular_component	chromosome, centromeric region
T	0000776	cellular_component	kinetochore
T	0000922	cellular_component	spindle pole
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005694	cellular_component	chromosome
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0007094	biological_process	mitotic spindle assembly checkpoint signaling
T	0033597	cellular_component	mitotic checkpoint complex
T	0042177	biological_process	negative regulation of protein catabolic process
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0043066	biological_process	negative regulation of apoptotic process
T	0044615	cellular_component	nuclear pore nuclear basket
T	0045930	biological_process	negative regulation of mitotic cell cycle
T	0048471	cellular_component	perinuclear region of cytoplasm
T	0051301	biological_process	cell division
T	0051660	biological_process	establishment of centrosome localization
T	0072686	cellular_component	mitotic spindle
T	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
T	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
T	1990728	cellular_component	mitotic spindle assembly checkpoint MAD1-MAD2 complex
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005680	cellular_component	anaphase-promoting complex
W	0005829	cellular_component	cytosol
W	0007346	biological_process	regulation of mitotic cell cycle
W	0016567	biological_process	protein ubiquitination
W	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
W	0051301	biological_process	cell division
W	0051445	biological_process	regulation of meiotic cell cycle
W	0070936	biological_process	protein K48-linked ubiquitination
W	0070979	biological_process	protein K11-linked ubiquitination
X	0000792	cellular_component	heterochromatin
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005680	cellular_component	anaphase-promoting complex
X	0005737	cellular_component	cytoplasm
X	0005819	cellular_component	spindle
X	0005829	cellular_component	cytosol
X	0005856	cellular_component	cytoskeleton
X	0007346	biological_process	regulation of mitotic cell cycle
X	0007420	biological_process	brain development
X	0015630	cellular_component	microtubule cytoskeleton
X	0016567	biological_process	protein ubiquitination
X	0019903	molecular_function	protein phosphatase binding
X	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
X	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
X	0051301	biological_process	cell division
X	0051445	biological_process	regulation of meiotic cell cycle
X	0070936	biological_process	protein K48-linked ubiquitination
X	0070979	biological_process	protein K11-linked ubiquitination
X	0140767	molecular_function	enzyme-substrate adaptor activity
Y	0000792	cellular_component	heterochromatin
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005680	cellular_component	anaphase-promoting complex
Y	0005737	cellular_component	cytoplasm
Y	0005819	cellular_component	spindle
Y	0005829	cellular_component	cytosol
Y	0005856	cellular_component	cytoskeleton
Y	0007346	biological_process	regulation of mitotic cell cycle
Y	0007420	biological_process	brain development
Y	0015630	cellular_component	microtubule cytoskeleton
Y	0016567	biological_process	protein ubiquitination
Y	0019903	molecular_function	protein phosphatase binding
Y	0031145	biological_process	anaphase-promoting complex-dependent catabolic process
Y	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
Y	0051301	biological_process	cell division
Y	0051445	biological_process	regulation of meiotic cell cycle
Y	0070936	biological_process	protein K48-linked ubiquitination
Y	0070979	biological_process	protein K11-linked ubiquitination
Y	0140767	molecular_function	enzyme-substrate adaptor activity

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. TGGGtsDrHIRIWNV

Chain	Residue	Details
R	THR373-VAL387

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WVM3

Chain	Residue	Details
J	SER595
K	GLU112
K	SER490
K	SER595
X	THR229
Y	THR229

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	THR430
B	HIS58
B	CYS59
B	CYS73
B	CYS76
T	SER6
T	SER130
T	SER185
H	THR209
H	THR244
H	THR313
H	THR430

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:12574116

Chain	Residue	Details
H	GLU435
T	SER170
T	SER178
H	SER291

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:12574116, ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	SER153
R	SER161
S	SER92
S	SER153
S	SER161
T	SER195
R	SER92
S	SER72

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:14657031

Chain	Residue	Details
R	THR106
S	THR106
Q	SER697

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15525512

Chain	Residue	Details
S	THR157
R	THR157

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21926987

Chain	Residue	Details
H	GLU386
R	LYS490
S	LYS485
S	LYS490
R	LYS485

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:19015317, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
Q	GLU670
H	GLU426

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PLK1 => ECO:0000269|PubMed:17785528

Chain	Residue	Details
H	SER821
Q	SER676

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PLK1 => ECO:0000269|PubMed:17376779

Chain	Residue	Details
Q	THR792
Q	THR1008

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
P	LYS147
Q	THR1042

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:19015317

Chain	Residue	Details
Q	GLU1043

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:14657031

Chain	Residue	Details
A	TYR571

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
A	SER686

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:14657031, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	GLU688

---