5KE4
Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 6 nicotinic acetylcholine receptor in complex with 2-((5-(3,7-Diazabicyclo[3.3.1]nonan-3-yl)pyridin-3-yl)oxy)- N,N-dimethylethanamine (BPC)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Soluble acetylcholine receptor | polymer | 230 | 26272.2 | 5 | UniProt (Q8WSF8) Pfam (PF02931) In PDB | Aplysia californica (California sea hare) | |
| 2 | A, B, C, E | 2-((5-(3,7-Diazabicyclo[3.3.1]nonan-3-yl)pyridin-3-yl)oxy)-N,N-dimethylethanamine | non-polymer | 290.4 | 4 | Chemie (6S7) | |||
| 3 | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 219 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Asp -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Trp 55 | Tyr 72 | conflict |
| Lys 183 | Arg 200 | conflict |
| His 184 | Gln 201 | conflict |
| Asp 185 | Val 202 | conflict |
| Ile 186 | Gln 203 | conflict |
| Lys 187 | His 204 | conflict |
| Asn 189 | Ser 206 | conflict |
| Glu 192 | Pro 209 | conflict |
| Ile 194 | Pro 211 | conflict |
| Thr 196 | Ile 213 | conflict |
| Ser 220 | - | expression tag |
| Arg 221 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 131360.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1161.6 | |
| All* | Total formula weight | 132522.5 |
