5KE4

Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 6 nicotinic acetylcholine receptor in complex with 2-((5-(3,7-Diazabicyclo[3.3.1]nonan-3-yl)pyridin-3-yl)oxy)- N,N-dimethylethanamine (BPC)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 6S7 A 301

Chain	Residue
A	TYR93
E	ILE118
A	TRP147
A	TYR188
A	GLU193
A	TYR195
A	HOH424
E	TRP55
E	VAL108
E	MET116

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site_id	AC2
Number of Residues	12
Details	binding site for residue 6S7 B 301

Chain	Residue
A	TRP55
A	ASP77
A	VAL108
A	MET116
A	ILE118
B	TYR93
B	TRP147
B	VAL148
B	TYR188
B	GLU193
B	TYR195
B	HOH412

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site_id	AC3
Number of Residues	11
Details	binding site for residue 6S7 C 301

Chain	Residue
B	TRP55
B	ASP77
B	VAL108
B	MET116
B	ILE118
C	TYR93
C	TRP147
C	TYR188
C	GLU193
C	TYR195
C	HOH421

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site_id	AC4
Number of Residues	11
Details	binding site for residue 6S7 E 301

Chain	Residue
D	TRP55
D	VAL108
D	MET116
D	ILE118
D	HOH326
E	TYR93
E	TRP147
E	VAL148
E	TYR188
E	GLU193
E	TYR195

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