5K8W
Crystal structure of mouse CARM1 in complex with inhibitor U2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 4 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) In PDB | Mus musculus (Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
2 | A, B, C, D | 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine | non-polymer | 337.4 | 4 | Chemie (GJV) | |||
3 | A, C, D | 1,2-DIMETHOXYETHANE | non-polymer | 90.1 | 6 | Chemie (DXE) | |||
4 | A, B, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
6 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
7 | water | water | 18.0 | 1198 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 487 (UniProt: Q9WVG6)
PDB | External Database | Details |
---|---|---|
Gly 127 | - | expression tag |
His 128 | - | expression tag |
Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 163401.8 | |
Non-Polymers* | Number of molecules | 22 |
Total formula weight | 2855.2 | |
All* | Total formula weight | 166257.1 |