5K7U
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | N6-adenosine-methyltransferase 70 kDa subunit | polymer | 225 | 25732.5 | 1 | UniProt (Q86U44) Pfam (PF05063) In PDB | Homo sapiens (Human) | MT-A70,Methyltransferase-like protein 3 |
| 2 | B | N6-adenosine-methyltransferase subunit METTL14 | polymer | 349 | 39573.7 | 1 | UniProt (Q9HCE5) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 14 |
| 3 | A | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | water | water | 18.0 | 530 | Chemie (HOH) |
Sequence modifications
A: 357 - 580 (UniProt: Q86U44)
B: 111 - 456 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gly 110 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65306.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 398.4 | |
| All* | Total formula weight | 65704.6 |
