5K7U
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue SAM A 601 |
| Chain | Residue |
| A | CYS376 |
| A | ARG536 |
| A | HIS538 |
| A | ASN539 |
| A | ASN549 |
| A | GLN550 |
| A | HOH725 |
| A | HOH748 |
| A | HOH762 |
| A | HOH800 |
| A | ASP377 |
| A | ILE378 |
| A | ASP395 |
| A | PRO397 |
| A | LEU409 |
| A | HIS512 |
| A | LYS513 |
| A | PHE534 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | SITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
| Chain | Residue | Details |
| B | TYR146 | |
| B | ASP242 | |
| B | ARG245 | |
| B | ARG298 | |
| B | SER399 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:29348140, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER399 | |
| A | LYS513 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2 |
| Chain | Residue | Details |
| A | GLU438 | |
| A | ARG441 |
