5K7U

Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0005634	cellular_component	nucleus
A	0016422	molecular_function	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue SAM A 601

Chain	Residue
A	CYS376
A	ARG536
A	HIS538
A	ASN539
A	ASN549
A	GLN550
A	HOH725
A	HOH748
A	HOH762
A	HOH800
A	ASP377
A	ILE378
A	ASP395
A	PRO397
A	LEU409
A	HIS512
A	LYS513
A	PHE534

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	SITE: Interaction with METTL3 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2

Chain	Residue	Details
B	TYR146
B	ASP242
B	ARG245
B	ARG298
B	SER399

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:27281194, ECO:0000269|PubMed:29348140, ECO:0007744|PDB:5IL0, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER399
A	LYS513

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Interaction with METTL14 => ECO:0000269|PubMed:27281194, ECO:0007744|PDB:5IL1, ECO:0007744|PDB:5IL2

Chain	Residue	Details
A	GLU438
A	ARG441

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