5K6I
Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C, S46G-E92D-S215P-K465Q variant.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Fusion glycoprotein F0 | polymer | 445 | 49182.1 | 1 | UniProt (P03420) Pfam (PF00523) | Human respiratory syncytial virus A (strain A2) | Protein F,Protein F |
| 2 | B, C (F) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E (F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | F (F) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | G, H (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | I (F) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
F: 26 - 103 (UniProt: P03420)
F: 145 - 509 (UniProt: P03420)
| PDB | External Database | Details |
|---|---|---|
| Gly 46 | Ser 46 | engineered mutation |
| Asp 92 | Glu 92 | engineered mutation |
| Ala 102 | Pro 102 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | linker |
| Ser 144 | - | linker |
| Cys 149 | Ala 149 | engineered mutation |
| Cys 155 | Ser 155 | engineered mutation |
| Phe 190 | Ser 190 | engineered mutation |
| Leu 207 | Val 207 | engineered mutation |
| Pro 215 | Ser 215 | engineered mutation |
| Cys 290 | Ser 290 | engineered mutation |
| Arg 373 | Leu 373 | engineered mutation |
| Val 379 | Ile 379 | engineered mutation |
| Val 447 | Met 447 | engineered mutation |
| Cys 458 | Tyr 458 | engineered mutation |
| Gln 465 | Lys 465 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 49182.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 792.3 | |
| All* | Total formula weight | 49974.4 |
