5K3N
Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Nuclear receptor ROR-gamma | polymer | 247 | 28721.3 | 4 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | A, B, C, D | (3S)-3-(2H-1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one | non-polymer | 441.5 | 4 | Chemie (6Q6) | |||
| 3 | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 265 - 507 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 261 | - | expression tag |
| Ser 262 | - | expression tag |
| His 263 | - | expression tag |
| Met 264 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 114885.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1766.1 | |
| All* | Total formula weight | 116651.2 |
