5K1V

Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a diaminobenzoic acid derivative ligand.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Endoplasmic reticulum aminopeptidase 2	polymer	967	111578.5	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	Homo sapiens (Human)	Leukocyte-derived arginine aminopeptidase,L-RAP
2	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
3	E	alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81874LD)
4	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A	methyl N-[4-amino-3-(L-arginylamino)benzene-1-carbonyl]-L-tyrosinate	non-polymer		485.5	1	Chemie (6PX)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)
7		water	water		18.0	44	Chemie (HOH)

Sequence modifications

A, B: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Arg 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	223157.0
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	15
	Total formula weight	3270.9
All*	Total formula weight	228025.3

*Water molecules are not included.