5K0M
Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Polycomb protein EED | polymer | 372 | 42936.9 | 1 | UniProt (O75530) Pfam (PF00400) In PDB | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
2 | A | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine | non-polymer | 486.6 | 1 | Chemie (6PU) | |||
3 | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A: 77 - 441 (UniProt: O75530)
PDB | External Database | Details |
---|---|---|
Val 70 | - | expression tag |
Pro 71 | - | expression tag |
Arg 72 | - | expression tag |
Gly 73 | - | expression tag |
Ser 74 | - | expression tag |
His 75 | - | expression tag |
Met 76 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42936.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 486.6 | |
All* | Total formula weight | 43423.6 |