5JWM
Bivalent BET Bromodomain Inhibition
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bromodomain-containing protein 4 | polymer | 130 | 15060.3 | 2 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
2 | A | 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide | non-polymer | 1134.2 | 1 | Chemie (6ON) | |||
3 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B: 333 - 460 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Ser 331 | - | expression tag |
Met 332 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 30120.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 1134.2 | |
All* | Total formula weight | 31254.9 |