5JTY
Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1 | polymer | 292 | 33340.0 | 1 | UniProt (P35439) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1,GluN1,Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1 |
| 2 | B | Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A | polymer | 281 | 31533.1 | 1 | UniProt (Q00959) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A,GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A |
| 3 | A | 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid | non-polymer | 217.2 | 1 | Chemie (2JK) | |||
| 4 | B | 5-({[(3,4-difluorophenyl)sulfonyl]amino}methyl)-6-methyl-N-[(2-methyl-1,3-thiazol-5-yl)methyl]pyrazine-2-carboxamide | non-polymer | 453.5 | 1 | Chemie (6ND) | |||
| 5 | B | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,hNR2A,GluN2A,Glutamate [NMDA] receptor subunit epsilon-1,N-methyl D-aspartate receptor subtype 2A,NR2A | ||
| 6 | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A: 2 - 152 (UniProt: P35439)
A: 155 - 292 (UniProt: P35439)
B: 5 - 142 (UniProt: Q00959)
B: 145 - 284 (UniProt: Q00959)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | linker |
| Thr 154 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 143 | - | linker |
| Thr 144 | - | linker |
| Thr 242 | Ser 758 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64873.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 817.8 | |
| All* | Total formula weight | 65690.9 |
