5JR2
Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Ephrin type-A receptor 4 | polymer | 179 | 20489.1 | 4 | UniProt (P54764) Pfam (PF01404) In PDB | Homo sapiens (Human) | EPH-like kinase 8,hEK8,Tyrosine-protein kinase TYRO1,Tyrosine-protein kinase receptor SEK |
| 2 | E, F, G, H | APYd3 peptide | polymer | 13 | 1404.6 | 4 | synthetic construct | ||
| 3 | A, B, C | HEXANE-1,6-DIOL | non-polymer | 118.2 | 6 | Chemie (HEZ) | |||
| 4 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 685 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 29 - 204 (UniProt: P54764)
| PDB | External Database | Details |
|---|---|---|
| Gly 26 | - | expression tag |
| Pro 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ala 204 | Cys 204 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 87575.0 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1445.8 | |
| All* | Total formula weight | 89020.8 |
