5JR2

Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue HEZ A 301

Chain	Residue
A	ILE170
A	ARG171
A	LYS202
A	HOH463
A	HOH472
A	HOH520

---

site_id	AC2
Number of Residues	11
Details	binding site for residue HEZ A 302

Chain	Residue
A	ARG85
A	ILE137
A	GLU139
A	PHE142
A	HOH439
A	HOH455
D	LEU50
D	GLU51
A	SER48
A	ASN81
A	TRP83

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 303

Chain	Residue
A	GLU30
A	GLU100
A	ARG198

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 304

Chain	Residue
A	ARG96
A	ASP172
A	VAL173
A	GLY174
A	HOH434
A	HOH438
A	HOH522

---

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 305

Chain	Residue
A	ASP158
A	GLY160

---

site_id	AC6
Number of Residues	4
Details	binding site for residue HEZ B 301

Chain	Residue
B	ILE170
B	ARG171
B	LYS202
B	HOH467

---

site_id	AC7
Number of Residues	6
Details	binding site for residue HEZ B 302

Chain	Residue
B	THR104
B	LEU105
B	PHE154
B	LYS165
B	ASN167
B	HOH476

---

site_id	AC8
Number of Residues	9
Details	binding site for residue HEZ B 303

Chain	Residue
B	GLY93
B	ALA94
B	GLN95
B	ARG96
B	TYR201
B	LYS202
B	HOH402
B	HOH460
B	HOH525

---

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL B 304

Chain	Residue
B	PRO27
B	GLU30
B	GLU100
B	ARG198

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL B 305

Chain	Residue
B	ASP158
B	GLY160
B	HOH404

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL B 306

Chain	Residue
B	ARG96
B	ASP172
B	VAL173
B	GLY174
B	HOH457

---

site_id	AD3
Number of Residues	9
Details	binding site for residue HEZ C 301

Chain	Residue
C	SER48
C	ARG85
C	ILE137
C	GLU139
C	PHE142
C	HOH403
C	HOH478
C	HOH499
C	HOH533

---

site_id	AD4
Number of Residues	6
Details	binding site for residue GOL C 302

Chain	Residue
C	ARG96
C	ASP172
C	VAL173
C	GLY174
C	HOH455
C	HOH490

---

site_id	AD5
Number of Residues	5
Details	binding site for residue GOL D 301

Chain	Residue
D	ARG96
D	ASP172
D	VAL173
D	GLY174
D	HOH483

---

site_id	AD6
Number of Residues	5
Details	binding site for Di-peptide BAL E 1 and PRO E 2

Chain	Residue
A	CYS73
A	ASN74
A	GLU77
E	TYR3
E	CYS4

---

site_id	AD7
Number of Residues	7
Details	binding site for Di-peptide ARG E 7 and BAL E 8

Chain	Residue
A	ARG162
A	HOH452
E	VAL5
E	TYR6
E	SER9
E	HOH103
E	HOH105

---

site_id	AD8
Number of Residues	6
Details	binding site for Di-peptide BAL E 8 and SER E 9

Chain	Residue
A	ARG162
E	TYR6
E	ARG7
E	TRP10
E	SER11
E	HOH102

---

site_id	AD9
Number of Residues	3
Details	binding site for Di-peptide CYS E 12 and NH2 E 13

Chain	Residue
E	CYS4
E	SER11
E	TYR3

---

site_id	AE1
Number of Residues	6
Details	binding site for Di-peptide BAL F 1 and PRO F 2

Chain	Residue
B	CYS73
B	ASN74
B	GLU77
F	TYR3
F	CYS4
F	HOH102

---

site_id	AE2
Number of Residues	7
Details	binding site for Di-peptide ARG F 7 and BAL F 8

Chain	Residue
B	ARG162
B	HOH420
F	VAL5
F	TYR6
F	SER9
F	HOH106
F	HOH108

---

site_id	AE3
Number of Residues	5
Details	binding site for Di-peptide BAL F 8 and SER F 9

Chain	Residue
B	ARG162
F	TYR6
F	ARG7
F	TRP10
F	HOH104

---

site_id	AE4
Number of Residues	3
Details	binding site for Di-peptide CYS F 12 and NH2 F 13

Chain	Residue
F	TYR3
F	CYS4
F	SER11

---

site_id	AE5
Number of Residues	9
Details	binding site for Di-peptide BAL G 1 and PRO G 2

Chain	Residue
C	CYS73
C	ASN74
C	GLU77
D	PRO112
D	GLY113
D	HOH463
G	TYR3
G	CYS4
G	HOH102

---

site_id	AE6
Number of Residues	7
Details	binding site for Di-peptide ARG G 7 and BAL G 8

Chain	Residue
C	ILE59
C	HOH480
G	VAL5
G	TYR6
G	SER9
G	HOH103
G	HOH105

---

site_id	AE7
Number of Residues	7
Details	binding site for Di-peptide BAL G 8 and SER G 9

Chain	Residue
C	ARG162
C	HOH404
G	TYR6
G	ARG7
G	TRP10
G	SER11
G	HOH103

---

site_id	AE8
Number of Residues	7
Details	binding site for Di-peptide CYS G 12 and NH2 G 13

Chain	Residue
D	GLY113
D	MET115
D	HOH468
G	TYR3
G	CYS4
G	SER11
G	HOH106

---

site_id	AE9
Number of Residues	9
Details	binding site for Di-peptide BAL H 1 and PRO H 2

Chain	Residue
D	GLY52
D	CYS73
D	ASN74
D	GLU77
D	HOH456
H	TYR3
H	CYS4
H	HOH102
H	HOH104

---

site_id	AF1
Number of Residues	7
Details	binding site for Di-peptide ARG H 7 and BAL H 8

Chain	Residue
D	ILE59
D	ARG162
D	HOH431
H	VAL5
H	TYR6
H	SER9
H	HOH101

---

site_id	AF2
Number of Residues	5
Details	binding site for Di-peptide BAL H 8 and SER H 9

Chain	Residue
H	TYR6
H	ARG7
H	TRP10
H	SER11
H	HOH101

---

site_id	AF3
Number of Residues	5
Details	binding site for Di-peptide CYS H 12 and NH2 H 13

Chain	Residue
H	TYR3
H	CYS4
H	SER11
H	HOH106
H	HOH107

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