5JMO

X-ray structure of furin in complex with the inhibitory antibody Nb14

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Furin	polymer	482	52388.6	2	UniProt (P09958) Pfam (PF00082) Pfam (PF01483)	Homo sapiens (Human)	Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
2	C, D (C, D)	camelid VHH fragment	polymer	117	12615.0	2		Camelus dromedarius (Arabian camel)
3	E, F (G, H)	CMK-inhibitor	polymer	6	749.5	2	BIRD (PRD_000278)	synthetic construct
4	G, H, M, N (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	I, J, K, O, P... (A, B)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
6	L, R (A, B)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7	S, T, U, V, W... (A, B, C, D, G...)	water	water		18.0	769	Chemie (HOH)

Sequence modifications

A, B: 108 - 574 (UniProt: P09958)

PDB	External Database	Details
Ser 575	-	expression tag
Gly 576	-	expression tag
Ser 577	-	expression tag
Leu 578	-	expression tag
Val 579	-	expression tag
Pro 580	-	expression tag
Arg 581	-	expression tag
Gly 582	-	expression tag
Ser 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	131506.1
Non-Polymers*	Number of molecules	12
	Total formula weight	1171.3
All*	Total formula weight	132677.4

*Water molecules are not included.