5JMO
X-ray structure of furin in complex with the inhibitory antibody Nb14
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Furin | polymer | 482 | 52388.6 | 2 | UniProt (P09958) Pfam (PF00082) Pfam (PF01483) In PDB | Homo sapiens (Human) | Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE |
2 | C, D | camelid VHH fragment | polymer | 117 | 12615.0 | 2 | Camelus dromedarius (Arabian camel) | ||
3 | G, H | CMK-inhibitor | polymer | 6 | 749.5 | 2 | BIRD (PRD_000278) | synthetic construct | |
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
5 | A, B | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
6 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
7 | water | water | 18.0 | 769 | Chemie (HOH) |
Sequence modifications
A, B: 108 - 574 (UniProt: P09958)
PDB | External Database | Details |
---|---|---|
Ser 575 | - | expression tag |
Gly 576 | - | expression tag |
Ser 577 | - | expression tag |
Leu 578 | - | expression tag |
Val 579 | - | expression tag |
Pro 580 | - | expression tag |
Arg 581 | - | expression tag |
Gly 582 | - | expression tag |
Ser 583 | - | expression tag |
His 584 | - | expression tag |
His 585 | - | expression tag |
His 586 | - | expression tag |
His 587 | - | expression tag |
His 588 | - | expression tag |
His 589 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 131506.1 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1171.3 | |
All* | Total formula weight | 132677.4 |