5JJY
Crystal structure of SETD2 bound to histone H3.3 K36M peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETD2 | polymer | 279 | 32042.6 | 1 | UniProt (Q9BYW2) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,SET domain-containing protein 2,hSET2,p231HBP |
| 2 | B (B) | Histone H3.3 | polymer | 14 | 1560.8 | 1 | UniProt (P84243) | Homo sapiens | |
| 3 | C, D, E (A) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | F (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 5 | G, H, I, J, K (A, B) | THIOCYANATE ION | non-polymer | 58.1 | 5 | Chemie (SCN) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 1434 - 1711 (UniProt: Q9BYW2)
B: 29 - 42 (UniProt: P84243)
| PDB | External Database | Details |
|---|---|---|
| Ser 1433 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 36 | Lys 37 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33603.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 871.0 | |
| All* | Total formula weight | 34474.4 |
