5JIK

Crystal structure of HER2 binding IgG1-Fc (Fcab H10-03-6)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ig gamma-1 chain C region	polymer	227	25641.1	2	UniProt (P01857) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1114.0	1	In PDB GlyTouCan (G64481DJ)
3	D	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4		water	water		18.0	106	Chemie (HOH)

Sequence modifications

A, B: 225 - 446 (UniProt: P01857)

PDB	External Database	Details
Tyr 358	Leu 241	engineered mutation
Leu 359	Thr 242	engineered mutation
Tyr 360	Lys 243	engineered mutation
Gly 361	Asn 244	engineered mutation
Asp 362	Gln 245	engineered mutation
Pro 413	Asp 296	engineered mutation
Arg 414	Lys 297	engineered mutation
His 415	Ser 298	engineered mutation
Ser 415	-	insertion
Ala 415	-	insertion
Arg 415	-	insertion
Met 415	-	insertion
Trp 415	-	insertion
Ala 418	Gln 301	engineered mutation
His 419	Gln 302	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51282.1
Branched	Number of molecules	2
	Total formula weight	2024.8
All*	Total formula weight	53307.0

*Water molecules are not included.