5JI0
PPARgamma-RXRalpha(S427F) heterodimer in complex with SRC-1, rosiglitazone, and 9-cis-retanoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 242 | 27104.4 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (D) | Peroxisome proliferator-activated receptor gamma | polymer | 273 | 31151.2 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 3 | C, D (E, F) | Nuclear receptor coactivator 1 | polymer | 27 | 2830.2 | 2 | UniProt (Q15788) Pfam (PF08832) | Homo sapiens | NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
| 4 | E (A) | (9cis)-retinoic acid | non-polymer | 300.4 | 1 | Chemie (9CR) | |||
| 5 | F (D) | 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) | non-polymer | 357.4 | 1 | Chemie (BRL) | |||
| 6 | G, H, I (A, D, E) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: 223 - 462 (UniProt: P19793)
D: 206 - 477 (UniProt: P37231)
E, F: 676 - 700 (UniProt: Q15788)
| PDB | External Database | Details |
|---|---|---|
| Gly 221 | - | expression tag |
| Met 222 | - | expression tag |
| Phe 427 | Ser 427 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 205 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 675 | - | acetylation |
| Nh2 701 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 63916.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 657.9 | |
| All* | Total formula weight | 64573.8 |
