5JH5

Structural Basis for the Hierarchical Assembly of the Core of PRC1.1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lysine-specific demethylase 2B	polymer	281	32494.6	1	UniProt (Q8NHM5) Pfam (PF12937) In PDB	Homo sapiens (Human)	CXXC-type zinc finger protein 2,F-box and leucine-rich repeat protein 10,F-box protein FBL10,F-box/LRR-repeat protein 10,JmjC domain-containing histone demethylation protein 1B,Jumonji domain-containing EMSY-interactor methyltransferase motif protein,Protein JEMMA,Protein-containing CXXC domain 2,[Histone-H3]-lysine-36 demethylase 1B
2	B	S-phase kinase-associated protein 1	polymer	162	18689.5	1	UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB	Homo sapiens (Human)	Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1
3	C	Polycomb group RING finger protein 1	polymer	109	13205.9	1	UniProt (Q9BSM1) Pfam (PF16207) In PDB	Homo sapiens (Human)	Nervous system Polycomb-1,NSPc1,RING finger protein 68
4	D	BCL-6 corepressor-like protein 1	polymer	122	14164.6	1	UniProt (Q5H9F3) Pfam (PF16553) In PDB	Homo sapiens (Human)	BCoR-like protein 1
5		water	water		18.0	64	Chemie (HOH)

Sequence modifications

A: 1059 - 1336 (UniProt: Q8NHM5)

PDB	External Database	Details
Gly 1056	-	expression tag
Thr 1057	-	expression tag
Arg 1058	-	expression tag

C: 150 - 255 (UniProt: Q9BSM1)

PDB	External Database	Details
Gly 147	-	expression tag
Thr 148	-	expression tag
Arg 149	-	expression tag

D: 1594 - 1711 (UniProt: Q5H9F3)

PDB	External Database	Details
Mse 1590	-	initiating methionine
Glu 1591	-	expression tag
Thr 1592	-	expression tag
Arg 1593	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	78554.6
All*	Total formula weight	78554.6

*Water molecules are not included.