5JBC
Crystal structure of factor IXa variant V16I K98T Y177T I213V in complex with PPACK
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | E | Coagulation factor IX | polymer | 58 | 6395.3 | 1 | UniProt (P00740) Pfam (PF14670) In PDB | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 2 | S | Coagulation factor IX | polymer | 235 | 26100.7 | 1 | UniProt (P00740) Pfam (PF00089) In PDB | Homo sapiens (Human) | Christmas factor,Plasma thromboplastin component,PTC |
| 3 | S | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | S | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
| 5 | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
S: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Ile 16 | Val 227 | engineered mutation |
| Thr 98 | Lys 311 | engineered mutation |
| Thr 177 | Tyr 391 | engineered mutation |
| Val 213 | Ile 429 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32496.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 494.1 | |
| All* | Total formula weight | 32990.0 |
