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5J94

Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345

Replaces:  4LEG
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACathepsin Kpolymer22324539.51UniProt (P43235)
Pfam (PF00112)
In PDB
Homo sapiens (Human)Cathepsin O,Cathepsin O2,Cathepsin X
2A2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acidnon-polymer254.31Chemie (1XF)
3ASULFATE IONnon-polymer96.11Chemie (SO4)
4waterwater18.0132Chemie (HOH)
Sequence modifications
A: -7 - 215 (UniProt: P43235)
PDBExternal DatabaseDetails
Ser 25Cys 139engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight24539.5
Non-Polymers*Number of molecules2
Total formula weight350.3
All*Total formula weight24889.9
*Water molecules are not included.

221051

PDB entries from 2024-06-12

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