5J8K

Architecture of supercomplex I-III2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	COMPLEX I ND3	polymer	102	8698.7	1		Ovis aries (SHEEP)
2	B (B)	COMPLEX I PSST/NDUFS7	polymer	154	13196.3	1		Ovis aries (SHEEP)
3	C (C)	COMPLEX I 30KDA/NDUFS3	polymer	194	16528.3	1		Ovis aries (SHEEP)
4	D (D)	COMPLEX I 49KDA/NDUFS2	polymer	384	32698.2	1		Ovis aries (SHEEP)
5	E (E)	COMPLEX I 24KDA/NDUFV2	polymer	189	16175.0	1		Ovis aries (SHEEP)
6	F (F)	COMPLEX I 51KDA/NDUFV1	polymer	429	36600.1	1		Ovis aries (SHEEP)
7	G (G)	COMPLEX I 75KDA/NDUFS1	polymer	652	55758.0	1		Ovis aries (SHEEP)
8	H (H)	COMPLEX I ND1	polymer	297	25294.0	1		Ovis aries (SHEEP)
9	I (I)	COMPLEX I TYKY/NDUFS8	polymer	171	14715.2	1		Ovis aries (SHEEP)
10	J (J)	COMPLEX I ND6	polymer	171	14570.9	1		Ovis aries (SHEEP)
11	K (K)	COMPLEX I ND4L	polymer	93	7932.8	1		Ovis aries (SHEEP)
12	L (L)	COMPLEX I ND5	polymer	575	48953.4	1		Ovis aries (SHEEP)
13	M (M)	COMPLEX I ND4	polymer	455	38740.7	1		Ovis aries (SHEEP)
14	N (N)	COMPLEX I ND2	polymer	345	29379.1	1		Ovis aries (SHEEP)
15	O (O)	COMPLEX I 18KDA/NDUFS6	polymer	104	8868.9	1		Ovis aries (SHEEP)
16	P (P)	COMPLEX I 13KDA/NDUFS6	polymer	85	7251.9	1		Ovis aries (SHEEP)
17	Q (Q)	COMPLEX I 15KDA/NDUFS5	polymer	66	5634.9	1		Ovis aries (SHEEP)
18	R (R)	COMPLEX I MWFE/NDUFA1	polymer	29	2486.1	1		Ovis aries (SHEEP)
19	DA, S (S, d)	COMPLEX I B8/NDUFA2	polymer	80	6826.4	2		Ovis aries (SHEEP)
20	T (T)	COMPLEX I B9/NDUFA3	polymer	53	4528.6	1		Ovis aries (SHEEP)
21	U (U)	COMPLEX I B13/NDUFA5	polymer	96	8188.1	1		Ovis aries (SHEEP)
22	V (V)	COMPLEX I B14/NDUFA6	polymer	112	9549.8	1		Ovis aries (SHEEP)
23	W (W)	COMPLEX I PGIV/NDUFA8	polymer	103	8783.8	1		Ovis aries (SHEEP)
24	X (X)	COMPLEX I 39KDA/NDUFA9	polymer	309	26315.3	1		Ovis aries (SHEEP)
25	Y (Y)	COMPLEX I 42KDA/NDUFA10	polymer	322	27421.6	1		Ovis aries (SHEEP)
26	Z (Z)	COMPLEX I B14.7/NDUFA11	polymer	119	10145.5	1		Ovis aries (SHEEP)
27	AA (a)	COMPLEX I B17.2/NDUFA12	polymer	111	9464.7	1		Ovis aries (SHEEP)
28	BA (b)	COMPLEX I B16.6/NDUFA13	polymer	92	7847.7	1		Ovis aries (SHEEP)
29	CA (c)	COMPLEX I SDAP/NDUFAB1	polymer	79	6741.3	1		Ovis aries (SHEEP)
30	EA (e)	COMPLEX I B15/NDUFB4	polymer	55	4698.8	1		Ovis aries (SHEEP)
31	FA (f)	COMPLEX I B18/NDUFB7	polymer	59	5039.2	1		Ovis aries (SHEEP)
32	GA (g)	COMPLEX I B22/NDUFB9	polymer	130	11081.7	1		Ovis aries (SHEEP)
33	HA, UA, VA (h, 9, z)	COMPLEX I PDSW/NDUFB10	polymer	63	5379.6	3		Ovis aries (SHEEP)
34	IA (i)	COMPLEX I ESSS/NDUFB11	polymer	70	5975.4	1		Ovis aries (SHEEP)
35	JA (j)	COMPLEX I KFYI/NDUFC1	polymer	44	3762.6	1		Ovis aries (SHEEP)
36	KA (k)	COMPLEX I B14.5B/NDUFC2	polymer	83	7081.7	1		Ovis aries (SHEEP)
37	LA (0)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 1	polymer	36	3081.8	1		Ovis aries (SHEEP)
38	MA (1)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 2	polymer	30	2571.2	1		Ovis aries (SHEEP)
39	NA (2)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 3	polymer	38	3252.0	1		Ovis aries (SHEEP)
40	OA, PA (3, 4)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 4	polymer	28	2401.0	2		Ovis aries (SHEEP)
41	QA (5)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 5	polymer	34	2911.6	1		Ovis aries (SHEEP)
42	RA (6)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 6	polymer	21	1805.2	1		Ovis aries (SHEEP)
43	SA (7)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 7	polymer	39	3337.1	1		Ovis aries (SHEEP)
44	TA (8)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 8	polymer	27	2315.8	1		Ovis aries (SHEEP)
45	WA (y)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 11	polymer	46	3932.8	1		Ovis aries (SHEEP)
46	XA (x)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 12	polymer	13	1124.4	1		Ovis aries (SHEEP)
47	YA (w)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 13	polymer	24	2060.5	1		Ovis aries (SHEEP)
48	ZA (v)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 14	polymer	18	1549.9	1		Ovis aries (SHEEP)
49	AB (u)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 15	polymer	16	1379.7	1		Ovis aries (SHEEP)
50	BB (t)	COMPLEX I UNKNOWN SUBUNIT FRAGMENT 16	polymer	12	1039.3	1		Ovis aries (SHEEP)
51	CB, NB (AA, AL)	COMPLEX III SUBUNIT 1 / CORE 1	polymer	446	49385.4	2	UniProt (W5Q5G6) Pfam (PF00675) Pfam (PF05193)	Ovis aries (Sheep)
52	DB, OB (AB, AM)	COMPLEX III SUBUNIT 2 / CORE 2	polymer	423	45189.8	2	UniProt (W5Q0F9)	Ovis aries (Sheep)
53	EB, PB (AC, AN)	Cytochrome b	polymer	378	42684.6	2	UniProt (P24959) Pfam (PF00033) Pfam (PF00032)	Ovis aries (Sheep)	Complex III subunit 3,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
54	FB, QB (AD, AO)	COMPLEX III SUBUNIT 4 / CYTOCHROME C1	polymer	241	27323.3	2	UniProt (W5Q0A9)	Ovis aries (Sheep)
55	GB, RB (AE, AP)	Cytochrome b-c1 complex subunit Rieske, mitochondrial	polymer	196	21654.6	2	UniProt (W5P2X9)	Ovis aries (Sheep)
56	HB, SB (AF, AQ)	COMPLEX III SUBUNIT 7 / 14KDA	polymer	105	12949.8	2	UniProt (W5P642) Pfam (PF02271)	Ovis aries (Sheep)
57	IB, TB (AG, AR)	COMPLEX III SUBUNIT 8 / QP-C	polymer	75	8884.3	2	UniProt (W5PUP9) Pfam (PF02939)	Ovis aries (Sheep)
58	JB, UB (AH, AS)	Cytochrome b-c1 complex subunit 6	polymer	67	7920.9	2	UniProt (B9VH04)	Ovis aries (Sheep)	Complex III subunit 6,Mitochondrial hinge protein
59	KB, VB (AI, AT)	Cytochrome b-c1 complex subunit Rieske, mitochondrial	polymer	57	5824.8	2	UniProt (W5P2X9)	Ovis aries (Sheep)
60	LB, WB (AJ, AU)	COMPLEX III SUBUNIT 9 / 7.2KDA	polymer	60	6938.0	2	UniProt (W5P6B2)	Ovis aries (Sheep)
61	MB, XB (AK, AV)	COMPLEX III SUBUNIT 10 / 6.4KDA	polymer	51	5932.9	2	UniProt (W5PSD1)	Ovis aries (Sheep)
62	AC, BC, CC, EC, FC... (F, G, I, B)	IRON/SULFUR CLUSTER	non-polymer		351.6	6	Chemie (SF4)
63	DC, JC, NC, ZB (G, AE, AP, E)	FE2/S2 (INORGANIC) CLUSTER	non-polymer		175.8	4	Chemie (FES)
64	GC, HC, IC, KC, LC... (AC, AD, AN, AO)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	6	Chemie (HEM)

Sequence modifications

AA, AL: 1 - 446 (UniProt: W5Q5G6)

PDB	External Database	Details
Ile 241	Leu 275	conflict
Arg 242	Cys 276	conflict
Arg 244	Pro 278	conflict
Glu 245	Trp 279	conflict
Asp 246	Gly 280	conflict
-	Ala 283	deletion
-	Val 284	deletion
-	Pro 285	deletion
Pro 249	Gln 286	conflict
Ala 251	Trp 288	conflict
Ala 254	Pro 291	conflict
Ile 255	Phe 292	conflict
Ala 256	Gln 293	conflict
Val 257	Ile 294	conflict
Glu 258	Arg 295	conflict
Gly 259	His 296	conflict

AC, AN: 2 - 379 (UniProt: P24959)

PDB	External Database	Details
Ser 185	Phe 185	conflict
Ile 295	Val 295	conflict
Leu 303	Ile 303	conflict
Ile 359	Phe 359	conflict
Leu 361	Ile 361	conflict
Met 363	Leu 363	conflict

AD, AO: 1 - 241 (UniProt: W5Q0A9)

PDB	External Database	Details
Thr 139	-	insertion
Gly 140	Arg 223	conflict

AF, AQ: 6 - 110 (UniProt: W5P642)

PDB	External Database	Details
Asp 56	Asn 55	conflict
Ala 108	Thr 107	conflict

AK, AV: 1 - 51 (UniProt: W5PSD1)

PDB	External Database	Details
Gln 22	Ser 22	conflict

Contents of the asymmetric unit

Polymers	Number of chains	76
	Total formula weight	1074440.0
Non-Polymers*	Number of molecules	16
	Total formula weight	6512.0
All*	Total formula weight	1080952.1

*Water molecules are not included.