5J47
The X-ray structure of Inhibitor Bound to JCV Helicase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Large T antigen | polymer | 372 | 42389.0 | 1 | UniProt (P03072) Pfam (PF06431) | JC polyomavirus (JCPyV) | LT-AG |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | D (A) | 6-(2-phenoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | non-polymer | 294.3 | 1 | Chemie (6JJ) | |||
| 5 | E (A) | water | water | 18.0 | 350 | Chemie (HOH) |
Sequence modifications
A: 261 - 628 (UniProt: P03072)
| PDB | External Database | Details |
|---|---|---|
| Gly 257 | - | expression tag |
| Ser 258 | - | expression tag |
| His 259 | - | expression tag |
| Met 260 | - | expression tag |
| Asp 280 | Glu 280 | engineered mutation |
| Asn 295 | Asp 295 | engineered mutation |
| Ala 299 | Asn 299 | engineered mutation |
| Ala 301 | Gln 301 | engineered mutation |
| Ala 302 | Gln 302 | engineered mutation |
| Ala 304 | Lys 304 | engineered mutation |
| Ala 305 | Lys 305 | engineered mutation |
| Ala 307 | Glu 307 | engineered mutation |
| Ala 308 | Lys 308 | engineered mutation |
| Ala 309 | Lys 309 | engineered mutation |
| Leu 354 | Ile 354 | engineered mutation |
| Glu 408 | Asp 408 | engineered mutation |
| Ala 624 | Arg 624 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42389.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 555.0 | |
| All* | Total formula weight | 42944.0 |
