5J3S
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosyl-DNA phosphodiesterase 2 | polymer | 253 | 28824.3 | 1 | UniProt (O95551) Pfam (PF03372) In PDB | Homo sapiens (Human) | hTDP2,5'-tyrosyl-DNA phosphodiesterase,5'-Tyr-DNA phosphodiesterase,ETS1-associated protein 2,ETS1-associated protein II,EAPII,TRAF and TNF receptor-associated protein,Tyrosyl-RNA phosphodiesterase,VPg unlinkase |
| 2 | A | 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile | non-polymer | 382.3 | 1 | Chemie (6FQ) |
Sequence modifications
A: 113 - 360 (UniProt: O95551)
| PDB | External Database | Details |
|---|---|---|
| Gly 110 | - | expression tag |
| Ser 111 | - | expression tag |
| His 112 | - | expression tag |
| Ser 273 | Cys 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28824.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 382.3 | |
| All* | Total formula weight | 29206.6 |
