5J3S
Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue 6FQ A 401 |
| Chain | Residue |
| A | ARG231 |
| A | ARG266 |
| A | ILE307 |
| A | CYS311 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:27060144 |
| Chain | Residue | Details |
| A | ASP262 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27099339, ECO:0007744|PDB:5J3P |
| Chain | Residue | Details |
| A | ASP122 | |
| A | GLU152 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Interaction with 5' end of substrate DNA => ECO:0000250|UniProtKB:Q9JJX7 |
| Chain | Residue | Details |
| A | TYR178 | |
| A | TRP297 | |
| A | PHE315 | |
| A | HIS349 |
