5J3J

Crystal Structure of human DPP-IV in complex with HL1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Dipeptidyl peptidase 4	polymer	734	85261.5	2	UniProt (P27487) Pfam (PF00930) Pfam (PF00326)	Homo sapiens (Human)	ADABP,Adenosine deaminase complexing protein 2,ADCP-2,Dipeptidyl peptidase IV,DPP IV,T-cell activation antigen CD26,TP103
2	C (C)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		707.6	1	In PDB GlyTouCan (G99218JM)
3	D, F (A, B)	(2~{S},3~{R})-8,9-dimethoxy-3-[2,4,5-tris(fluoranyl)phenyl]-2,3-dihydro-1~{H}-benzo[f]chromen-2-amine	non-polymer		389.4	2	Chemie (HL1)
4	E, G (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	H, I (A, B)	water	water		18.0	96	Chemie (HOH)

Sequence modifications

A, B: 40 - 766 (UniProt: P27487)

PDB	External Database	Details
Gly 767	-	expression tag
His 768	-	expression tag
His 769	-	expression tag
His 770	-	expression tag
His 771	-	expression tag
His 772	-	expression tag
His 773	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	170523.0
Branched	Number of molecules	1
	Total formula weight	707.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1221.2
All*	Total formula weight	172451.8

*Water molecules are not included.