5J3H

Human insulin receptor domains L1-CR in complex with peptide S519C16 and 83-7 Fv

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Peptide S519C16	polymer	16	1950.0	1		Endothia gyrosa
2	B (C)	mAb 83-7 Fab heavy chain	polymer	123	13440.1	1		Mus musculus
3	C (D)	mAb 83-7 Fab light chain	polymer	118	13152.7	1		Mus musculus
4	D (E)	Insulin receptor	polymer	317	36231.8	1	UniProt (P06213) Pfam (PF01030) Pfam (PF00757)	Homo sapiens (Human)	IR
5	E (A)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
6	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
7	G (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1260.2	1	In PDB GlyTouCan (G07483YN)
8	H, I (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

E: 1 - 310 (UniProt: P06213)

PDB	External Database	Details
His 144	Tyr 171	conflict
Ser 311	-	expression tag
Ser 312	-	expression tag
Ser 313	-	expression tag
Leu 314	-	expression tag
Val 315	-	expression tag
Pro 316	-	expression tag
Arg 317	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	64774.6
Branched	Number of molecules	3
	Total formula weight	2255.1
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	67472.1

*Water molecules are not included.