5J2N
HIV-1 reverse transcriptase in complex with DNA that has incorporated EFdA-MP at the P-(post-translocation) site and dTMP at the N-(pre-translocation) site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | reverse transcriptase, p66 domain | polymer | 560 | 64521.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | Pr160Gag-Pol |
| 2 | B (B) | reverse transcriptase, p51 domain | polymer | 440 | 51383.0 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | Pr160Gag-Pol |
| 3 | C (P) | DNA 5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3' | polymer | 22 | 6820.5 | 1 | Human immunodeficiency virus 1 | ||
| 4 | D (T) | DNA (27-MER) | polymer | 27 | 8407.4 | 1 | Human immunodeficiency virus 1 | ||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G (A, T) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Cys 258 | Gln 845 | engineered mutation |
| Ser 280 | Cys 867 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 131132.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 24.3 | |
| All* | Total formula weight | 131157.1 |
