5J28

Ki67-PP1g (protein phosphatase 1, gamma isoform) holoenzyme complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	polymer	305	35044.4	2	UniProt (P36873) Pfam (PF16891) Pfam (PF00149)	Homo sapiens (Human)	PP-1G,Protein phosphatase 1C catalytic subunit
2	C, D (C, D)	Antigen KI-67	polymer	46	5187.0	2	UniProt (P46013) Pfam (PF15276)	Homo sapiens (Human)
3	E, G (A, B)	MALONATE ION	non-polymer		102.0	2	Chemie (MLI)
4	F (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	H, I, J, K (A, B, C, D)	water	water		18.0	232	Chemie (HOH)

Sequence modifications

A, B: 7 - 308 (UniProt: P36873)

PDB	External Database	Details
Gly 4	-	expression tag
His 5	-	expression tag
Met 6	-	expression tag

C, D: 496 - 536 (UniProt: P46013)

PDB	External Database	Details
Gly 491	-	expression tag
Ala 492	-	expression tag
Met 493	-	expression tag
Gly 494	-	expression tag
Tyr 495	-	expression tag
Met 525	Thr 525	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	80462.8
Non-Polymers*	Number of molecules	3
	Total formula weight	227.1
All*	Total formula weight	80689.8

*Water molecules are not included.