5J12
Structure of human TSLP:TSLPR in complex with mouse IL-7Ralpha
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Thymic stromal lymphopoietin | polymer | 163 | 18522.5 | 1 | UniProt (Q969D9) Pfam (PF15216) In PDB | Homo sapiens (Human) | |
2 | B | Interleukin-7 receptor subunit alpha | polymer | 223 | 25431.8 | 1 | UniProt (P16872) Pfam (PF18447) In PDB | Mus musculus (Mouse) | IL-7RA |
3 | C | Cytokine receptor-like factor 2 | polymer | 230 | 26559.5 | 1 | UniProt (Q9HC73) Pfam (PF22012) Pfam (PF21605) In PDB | Homo sapiens (Human) | Cytokine receptor-like 2,IL-XR,Thymic stromal lymphopoietin protein receptor,TSLP receptor |
4 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
5 | C | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
6 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: Q969D9)
B: 21 - 239 (UniProt: P16872)
C: 1 - 221 (UniProt: Q9HC73)
PDB | External Database | Details |
---|---|---|
Gln 64 | Asn 64 | engineered mutation |
- | Lys 126 | deletion |
- | Arg 127 | deletion |
- | Arg 128 | deletion |
- | Lys 129 | deletion |
- | Arg 130 | deletion |
Ser 131 | Lys 131 | engineered mutation |
Gly 160 | - | expression tag |
Thr 161 | - | expression tag |
Lys 162 | - | expression tag |
His 163 | - | expression tag |
His 164 | - | expression tag |
His 165 | - | expression tag |
His 166 | - | expression tag |
His 167 | - | expression tag |
His 168 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 17 | - | expression tag |
Ser 18 | - | expression tag |
His 19 | - | expression tag |
Met 20 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 222 | - | expression tag |
Thr 223 | - | expression tag |
Lys 224 | - | expression tag |
His 225 | - | expression tag |
His 226 | - | expression tag |
His 227 | - | expression tag |
His 228 | - | expression tag |
His 229 | - | expression tag |
His 230 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 70513.8 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 951.8 | |
All* | Total formula weight | 71465.7 |