5IXI

Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase JAK1	polymer	544	63362.3	1	UniProt (P23458) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990)	Homo sapiens (Human)	Janus kinase 1,JAK-1
2	B (B)	Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha	polymer	53	6136.1	1	UniProt (Q8IU57) UniProt (Q13651)	Homo sapiens (Human)	IFN-lambda-R1,Cytokine receptor class-II member 12,Cytokine receptor family 2 member 12,CRF2-12,Interleukin-28 receptor subunit alpha,IL-28RA,Likely interleukin or cytokine receptor 2,LICR2,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R1
3	C, D (A, B)	water	water		18.0	69	Chemie (HOH)

Sequence modifications

A: 35 - 559 (UniProt: P23458)

PDB	External Database	Details
Met 19	-	initiating methionine
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
His 23	-	expression tag
His 24	-	expression tag
His 25	-	expression tag
Gly 26	-	expression tag
Glu 27	-	expression tag
Asn 28	-	expression tag
Leu 29	-	expression tag
Tyr 30	-	expression tag
Phe 31	-	expression tag
Gln 32	-	expression tag
Gly 33	-	expression tag
Ser 34	-	expression tag
Asp 350	His 350	conflict
Phe 368	Tyr 368	conflict
Gly 560	-	expression tag
Asn 561	-	expression tag
Ser 562	-	expression tag

B: 253 - 262 (UniProt: Q8IU57)

PDB	External Database	Details
Gly 251	-	expression tag
Ser 252	-	expression tag

B: 263 - 303 (UniProt: Q13651)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69498.4
All*	Total formula weight	69498.4

*Water molecules are not included.