5IXI
Structure of human JAK1 FERM/SH2 in complex with IFNLR1/IL10RA chimera
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase JAK1 | polymer | 544 | 63362.3 | 1 | UniProt (P23458) Pfam (PF18379) Pfam (PF18377) Pfam (PF17887) Pfam (PF21990) In PDB | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
2 | B | Chimera protein of Interferon lambda receptor 1 and Interleukin-10 receptor subunit alpha | polymer | 53 | 6136.1 | 1 | UniProt (Q8IU57) UniProt (Q13651) In PDB | Homo sapiens (Human) | IFN-lambda-R1,Cytokine receptor class-II member 12,Cytokine receptor family 2 member 12,CRF2-12,Interleukin-28 receptor subunit alpha,IL-28RA,Likely interleukin or cytokine receptor 2,LICR2,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R1 |
3 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A: 35 - 559 (UniProt: P23458)
B: 253 - 262 (UniProt: Q8IU57)
B: 263 - 303 (UniProt: Q13651)
PDB | External Database | Details |
---|---|---|
Met 19 | - | initiating methionine |
His 20 | - | expression tag |
His 21 | - | expression tag |
His 22 | - | expression tag |
His 23 | - | expression tag |
His 24 | - | expression tag |
His 25 | - | expression tag |
Gly 26 | - | expression tag |
Glu 27 | - | expression tag |
Asn 28 | - | expression tag |
Leu 29 | - | expression tag |
Tyr 30 | - | expression tag |
Phe 31 | - | expression tag |
Gln 32 | - | expression tag |
Gly 33 | - | expression tag |
Ser 34 | - | expression tag |
Asp 350 | His 350 | conflict |
Phe 368 | Tyr 368 | conflict |
Gly 560 | - | expression tag |
Asn 561 | - | expression tag |
Ser 562 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 251 | - | expression tag |
Ser 252 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 69498.4 | |
All* | Total formula weight | 69498.4 |