5IV4
Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Adenylate cyclase type 10 | polymer | 475 | 54269.7 | 1 | UniProt (Q96PN6) Pfam (PF00211) | Homo sapiens (human) | AH-related protein,Adenylate cyclase homolog,Germ cell soluble adenylyl cyclase,sAC,Testicular soluble adenylyl cyclase |
| 2 | B (A) | 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine | non-polymer | 280.8 | 1 | Chemie (LRI) | |||
| 3 | C, D (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | E, F, G, H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | J, K, L, M (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 6 | N (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | O (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | P (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | Q (A) | water | water | 18.0 | 358 | Chemie (HOH) |
Sequence modifications
A: 1 - 469 (UniProt: Q96PN6)
| PDB | External Database | Details |
|---|---|---|
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
| His 473 | - | expression tag |
| His 474 | - | expression tag |
| His 475 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54269.7 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1255.4 | |
| All* | Total formula weight | 55525.1 |
