5IV4

Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue LRI A 501

Chain	Residue
A	PHE45
A	LEU102
A	PHE165
A	VAL167
A	VAL172
A	VAL175
A	ARG176
A	PHE336
A	MET337

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ACT A 502

Chain	Residue
A	ASP278
A	ASN279
A	GLN283

---

site_id	AC3
Number of Residues	7
Details	binding site for residue ACT A 503

Chain	Residue
A	LYS95
A	HIS164
A	ASN333
A	LYS334
A	VAL335
A	GOL515
A	HOH654

---

site_id	AC4
Number of Residues	3
Details	binding site for residue EDO A 504

Chain	Residue
A	GLN409
A	HOH606
A	HOH609

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 505

Chain	Residue
A	HOH755
A	HOH781
A	HOH840

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	PHE230
A	THR231
A	THR234
A	HOH807
A	HOH814

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 507

Chain	Residue
A	PRO31
A	GLY158
A	GLU160

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 508

Chain	Residue
A	ASN298
A	PHE336
A	PHE338
A	GLY341
A	SER343
A	HOH642

---

site_id	AC9
Number of Residues	6
Details	binding site for residue DMS A 509

Chain	Residue
A	TYR77
A	HIS78
A	ALA81
A	LEU129
A	PHE130
A	HOH951

---

site_id	AD1
Number of Residues	4
Details	binding site for residue DMS A 510

Chain	Residue
A	ILE88
A	PHE89
A	PHE226
A	PHE230

---

site_id	AD2
Number of Residues	5
Details	binding site for residue DMS A 511

Chain	Residue
A	ILE24
A	GLY27
A	PHE29
A	LEU261
A	TYR268

---

site_id	AD3
Number of Residues	7
Details	binding site for residue DMS A 512

Chain	Residue
A	PHE8
A	TRP11
A	SER80
A	HIS398
A	THR399
A	HOH630
A	HOH885

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL A 513

Chain	Residue
A	GLN409

---

site_id	AD5
Number of Residues	6
Details	binding site for residue PEG A 514

Chain	Residue
A	HIS162
A	HIS164
A	TYR318
A	THR322
A	LYS326
A	GLY330

---

site_id	AD6
Number of Residues	7
Details	binding site for residue GOL A 515

Chain	Residue
A	HIS19
A	PHE165
A	TYR268
A	LYS334
A	ACT503
A	HOH628
A	HOH654

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	137
Details	Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---