5IU2
Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase 8 | polymer | 332 | 37635.2 | 2 | UniProt (P41279) Pfam (PF00069) | Homo sapiens (human) | Cancer Osaka thyroid oncogene,Proto-oncogene c-Cot,Serine/threonine-protein kinase cot,Tumor progression locus 2,TPL-2 |
| 2 | C, D (A, B) | N-[2-(morpholin-4-yl)ethyl]-6-(8-phenyl-1H-imidazo[4,5-c][1,7]naphthyridin-1-yl)-1,3-benzothiazol-2-amine | non-polymer | 507.6 | 2 | Chemie (6DA) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A, B: 66 - 395 (UniProt: P41279)
| PDB | External Database | Details |
|---|---|---|
| Gly 64 | - | expression tag |
| Pro 65 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75270.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1015.2 | |
| All* | Total formula weight | 76285.6 |
