5ITY
Crystal Structure of Human NEIL1(P2G) bound to duplex DNA containing Thymine Glycol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Endonuclease 8-like 1 | polymer | 400 | 44885.3 | 3 | UniProt (Q96FI4) Pfam (PF01149) Pfam (PF09292) | Homo sapiens (Human) | DNA glycosylase/AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease VIII-like 1,FPG1,Nei homolog 1,NEH1,Nei-like protein 1 |
| 2 | D, E, F (D, E, F) | DNA (26-MER) | polymer | 26 | 7998.1 | 3 | unidentified | ||
| 3 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | H, I, J, K, L... (A, B, C, D, E...) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 390 (UniProt: Q96FI4)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | Pro 2 | engineered mutation |
| Arg 242 | Lys 242 | engineered mutation |
| Ala 391 | - | expression tag |
| Ala 392 | - | expression tag |
| Leu 393 | - | expression tag |
| Gly 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| His 399 | - | expression tag |
| His 400 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158650.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 158742.5 |
