5ISD
Crystal structure of mouse CARM1 in complex with inhibitor SA0592
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-arginine methyltransferase CARM1 | polymer | 361 | 40850.5 | 4 | UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528) | Mus musculus (Mouse) | Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4 |
| 2 | E, F, G, L, M... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 3 | H, I, N (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 4 | J (A) | 1-METHOXY-2-(2-METHOXYETHOXY)ETHANE | non-polymer | 134.2 | 1 | Chemie (M2M) | |||
| 5 | K, S, U (A, C, D) | 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine | non-polymer | 385.4 | 3 | Chemie (SAO) | |||
| 6 | O (B) | 5'-{[(3S)-3-amino-3-carboxypropyl](3-ethoxy-2,3-dioxopropyl)amino}-5'-deoxyadenosine | non-polymer | 481.5 | 1 | Chemie (6CZ) | |||
| 7 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 130 - 487 (UniProt: Q9WVG6)
| PDB | External Database | Details |
|---|---|---|
| Gly 127 | - | expression tag |
| His 128 | - | expression tag |
| Met 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 163401.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2648.9 | |
| All* | Total formula weight | 166050.7 |
