5ISD
Crystal structure of mouse CARM1 in complex with inhibitor SA0592
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| B | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| B | 0018216 | biological_process | peptidyl-arginine methylation |
| C | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| C | 0018216 | biological_process | peptidyl-arginine methylation |
| D | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| D | 0018216 | biological_process | peptidyl-arginine methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | M2M506 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | LEU280 |
| A | LYS281 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue PEG A 504 |
| Chain | Residue |
| A | HOH608 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue PEG A 505 |
| Chain | Residue |
| A | GLY284 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue M2M A 506 |
| Chain | Residue |
| A | TYR262 |
| A | GLU267 |
| A | HIS415 |
| A | TRP416 |
| A | EDO501 |
| A | TYR154 |
| A | MET163 |
| A | GLU258 |
| A | MET260 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | binding site for residue SAO A 507 |
| Chain | Residue |
| A | TYR150 |
| A | PHE151 |
| A | TYR154 |
| A | GLN160 |
| A | MET163 |
| A | ARG169 |
| A | GLY193 |
| A | CYS194 |
| A | GLY195 |
| A | ILE198 |
| A | GLU215 |
| A | ALA216 |
| A | GLY241 |
| A | LYS242 |
| A | VAL243 |
| A | GLU244 |
| A | MET269 |
| A | SER272 |
| A | HOH612 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 501 |
| Chain | Residue |
| B | ASP393 |
| B | TRP404 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 502 |
| Chain | Residue |
| B | PHE153 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 503 |
| Chain | Residue |
| B | GLN251 |
| B | LYS278 |
| site_id | AD1 |
| Number of Residues | 23 |
| Details | binding site for residue 6CZ B 504 |
| Chain | Residue |
| B | TYR150 |
| B | PHE151 |
| B | TYR154 |
| B | GLN160 |
| B | MET163 |
| B | ARG169 |
| B | GLY193 |
| B | CYS194 |
| B | GLY195 |
| B | ILE198 |
| B | GLU215 |
| B | ALA216 |
| B | GLY241 |
| B | LYS242 |
| B | VAL243 |
| B | GLU244 |
| B | GLU258 |
| B | MET260 |
| B | GLU267 |
| B | MET269 |
| B | SER272 |
| B | HIS415 |
| B | TRP416 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 501 |
| Chain | Residue |
| C | TYR150 |
| C | PHE153 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| C | TRP404 |
| site_id | AD4 |
| Number of Residues | 19 |
| Details | binding site for residue SAO C 504 |
| Chain | Residue |
| C | TYR150 |
| C | PHE151 |
| C | TYR154 |
| C | GLN160 |
| C | MET163 |
| C | ARG169 |
| C | GLY193 |
| C | CYS194 |
| C | ILE198 |
| C | GLU215 |
| C | ALA216 |
| C | GLY241 |
| C | LYS242 |
| C | VAL243 |
| C | GLU244 |
| C | GLU258 |
| C | MET269 |
| C | SER272 |
| C | HOH609 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 501 |
| Chain | Residue |
| D | ASP393 |
| D | TRP404 |
| site_id | AD6 |
| Number of Residues | 18 |
| Details | binding site for residue SAO D 502 |
| Chain | Residue |
| D | GLU244 |
| D | MET269 |
| D | SER272 |
| D | HOH609 |
| D | TYR150 |
| D | PHE151 |
| D | TYR154 |
| D | GLN160 |
| D | MET163 |
| D | ARG169 |
| D | GLY193 |
| D | CYS194 |
| D | GLY195 |
| D | ILE198 |
| D | LEU199 |
| D | GLU215 |
| D | ALA216 |
| D | VAL243 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1228 |
| Details | Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 132 |
| Details | Region: {"description":"Required for nuclear translocation","evidences":[{"source":"PubMed","id":"30366907","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17882261","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19843527","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q86X55","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
