5IS8

Crystal structure of mouse CARM1 in complex with inhibitor SA0271

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, D, C)	Histone-arginine methyltransferase CARM1	polymer	381	43109.8	4	UniProt (Q9WVG6) Pfam (PF06325) Pfam (PF22528)	Mus musculus (Mouse)	Coactivator-associated arginine methyltransferase 1,Protein arginine N-methyltransferase 4
2	E, H, K (A, B, C)	5'-{[(3S)-3-amino-3-carboxypropyl](2-chloroethyl)amino}-5'-deoxyadenosine	non-polymer		429.9	3	Chemie (6D1) PubChem (124220670)
3	F, G, J (A, D)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
4	I (D)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (13792) PubChem (177678424) PubChem (189149) PubChem (439155) PubChem (25210495) PubChem (21125603) PubChem (44361184) PubChem (25203782) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (52224400) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (5284331) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (71170554) PubChem (13231890) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (164157219) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
5	L, M, N, O (A, B, D, C)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

A, B, D, C: 130 - 507 (UniProt: Q9WVG6)

PDB	External Database	Details
Gly 127	-	expression tag
His 128	-	expression tag
Met 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	172439.2
Non-Polymers*	Number of molecules	7
	Total formula weight	1860.2
All*	Total formula weight	174299.4

*Water molecules are not included.