5IPF

Crystal structure of Hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni in complex with IMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)	polymer	250	28235.5	4	UniProt (G4LWQ2) Pfam (PF00156) UniProt (by SIFTS) (P09383)	Schistosoma mansoni (Blood fluke)	HGPRTase
2	E, F, G, H (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP)
3	I, J, K, L (A, B, C, D)	water	water		18.0	123	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 231 (UniProt: G4LWQ2)

PDB	External Database	Details
Met -18	-	initiating methionine
Ala -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112942.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1392.8
All*	Total formula weight	114334.9

*Water molecules are not included.