5IPF

Crystal structure of Hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni in complex with IMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)	polymer	250	28235.5	4	UniProt (G4LWQ2) Pfam (PF00156) UniProt (by SIFTS) (P09383)	Schistosoma mansoni (Blood fluke)	HGPRTase
2	E, F, G, H (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734)
3	I, J, K, L (A, B, C, D)	water	water		18.0	123	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 231 (UniProt: G4LWQ2)

PDB	External Database	Details
Met -18	-	initiating methionine
Ala -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112942.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1392.8
All*	Total formula weight	114334.9

*Water molecules are not included.