5IG6
Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with inhibitor 6B3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 2 | polymer | 115 | 13480.5 | 1 | UniProt (P25440) Pfam (PF00439) In PDB | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A | 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid | non-polymer | 434.4 | 1 | Chemie (6B3) | |||
| 5 | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 348 - 454 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| His 343 | - | expression tag |
| Met 344 | - | expression tag |
| Gln 345 | - | expression tag |
| Asp 346 | - | expression tag |
| Pro 347 | - | expression tag |
| Ala 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13480.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 689.5 | |
| All* | Total formula weight | 14170.0 |
