5IF8
Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to fragment hit EBSI-2643 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polymerase acidic protein | polymer | 464 | 53096.7 | 1 | UniProt (P15659) Pfam (PF00603) | Influenza A virus (strain A/Wilson-Smith/1933 H1N1) | RNA-directed RNA polymerase subunit P2 |
| 2 | B (A) | 5-[(4-chlorophenyl)methyl]-1,3,4-oxadiazol-2-amine | non-polymer | 209.6 | 1 | Chemie (6AX) | |||
| 3 | C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | G (A) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A: 254 - 716 (UniProt: P15659)
| PDB | External Database | Details |
|---|---|---|
| Gly 253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53096.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 477.4 | |
| All* | Total formula weight | 53574.1 |
