5IDE

Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Glutamate receptor 2	polymer	872	97663.2	2	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	B, D	Glutamate receptor 3	polymer	874	99075.7	2	UniProt (P19492) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Norway rat)	GluR-3,AMPA-selective glutamate receptor 3,GluR-C,GluR-K3,Glutamate receptor ionotropic,AMPA 3,GluA3

Sequence modifications

A, C: 2 - 862 (UniProt: P19491)

PDB	External Database	Details
Val -9	-	expression tag
Glu -8	-	expression tag
Gln -7	-	expression tag
Lys -6	-	expression tag
Leu -5	-	expression tag
Ile -4	-	expression tag
Ser -3	-	expression tag
Glu -2	-	expression tag
Glu -1	-	expression tag
Asp 0	-	expression tag
Leu 1	-	expression tag
Cys 292	Asn 313	engineered mutation

B, D: 2 - 866 (UniProt: P19492)

PDB	External Database	Details
Gly -7	-	expression tag
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Lys 1	-	expression tag
Cys 265	Arg 287	engineered mutation
Gly 439	Arg 461	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	393477.7
All*	Total formula weight	393477.7

*Water molecules are not included.