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5IDE

Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0001540molecular_functionamyloid-beta binding
A0001919biological_processregulation of receptor recycling
A0004970molecular_functionglutamate-gated receptor activity
A0004971molecular_functionAMPA glutamate receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005234molecular_functionextracellularly glutamate-gated ion channel activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0007268biological_processchemical synaptic transmission
A0008021cellular_componentsynaptic vesicle
A0008092molecular_functioncytoskeletal protein binding
A0008328cellular_componentionotropic glutamate receptor complex
A0009986cellular_componentcell surface
A0010226biological_processresponse to lithium ion
A0014069cellular_componentpostsynaptic density
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0015277molecular_functionkainate selective glutamate receptor activity
A0016020cellular_componentmembrane
A0019722biological_processcalcium-mediated signaling
A0019865molecular_functionimmunoglobulin binding
A0019901molecular_functionprotein kinase binding
A0021987biological_processcerebral cortex development
A0022849molecular_functionglutamate-gated calcium ion channel activity
A0022890molecular_functioninorganic cation transmembrane transporter activity
A0030165molecular_functionPDZ domain binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030672cellular_componentsynaptic vesicle membrane
A0031623biological_processreceptor internalization
A0032279cellular_componentasymmetric synapse
A0032281cellular_componentAMPA glutamate receptor complex
A0032590cellular_componentdendrite membrane
A0032839cellular_componentdendrite cytoplasm
A0032991cellular_componentprotein-containing complex
A0034220biological_processmonoatomic ion transmembrane transport
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035249biological_processsynaptic transmission, glutamatergic
A0035254molecular_functionglutamate receptor binding
A0035255molecular_functionionotropic glutamate receptor binding
A0036477cellular_componentsomatodendritic compartment
A0038023molecular_functionsignaling receptor activity
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043195cellular_componentterminal bouton
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043204cellular_componentperikaryon
A0043226cellular_componentorganelle
A0044326cellular_componentdendritic spine neck
A0044327cellular_componentdendritic spine head
A0044877molecular_functionprotein-containing complex binding
A0045184biological_processestablishment of protein localization
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0048787cellular_componentpresynaptic active zone membrane
A0050804biological_processmodulation of chemical synaptic transmission
A0050806biological_processpositive regulation of synaptic transmission
A0051262biological_processprotein tetramerization
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
A0060992biological_processresponse to fungicide
A0097060cellular_componentsynaptic membrane
A0097110molecular_functionscaffold protein binding
A0098655biological_processmonoatomic cation transmembrane transport
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098839cellular_componentpostsynaptic density membrane
A0098978cellular_componentglutamatergic synapse
A0099094molecular_functionligand-gated monoatomic cation channel activity
A0099505biological_processregulation of presynaptic membrane potential
A0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A0099544cellular_componentperisynaptic space
A0106033cellular_componentspine synapse
A1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
A1905430biological_processcellular response to glycine
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B0001540molecular_functionamyloid-beta binding
B0001919biological_processregulation of receptor recycling
B0004970molecular_functionglutamate-gated receptor activity
B0004971molecular_functionAMPA glutamate receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0008328cellular_componentionotropic glutamate receptor complex
B0010226biological_processresponse to lithium ion
B0014069cellular_componentpostsynaptic density
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0019722biological_processcalcium-mediated signaling
B0022849molecular_functionglutamate-gated calcium ion channel activity
B0022890molecular_functioninorganic cation transmembrane transporter activity
B0030425cellular_componentdendrite
B0032279cellular_componentasymmetric synapse
B0032281cellular_componentAMPA glutamate receptor complex
B0032991cellular_componentprotein-containing complex
B0034220biological_processmonoatomic ion transmembrane transport
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035249biological_processsynaptic transmission, glutamatergic
B0038023molecular_functionsignaling receptor activity
B0042734cellular_componentpresynaptic membrane
B0043025cellular_componentneuronal cell body
B0043083cellular_componentsynaptic cleft
B0043195cellular_componentterminal bouton
B0043197cellular_componentdendritic spine
B0043198cellular_componentdendritic shaft
B0043204cellular_componentperikaryon
B0043226cellular_componentorganelle
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0048787cellular_componentpresynaptic active zone membrane
B0050804biological_processmodulation of chemical synaptic transmission
B0051289biological_processprotein homotetramerization
B0051290biological_processprotein heterotetramerization
B0060078biological_processregulation of postsynaptic membrane potential
B0060291biological_processlong-term synaptic potentiation
B0060992biological_processresponse to fungicide
B0098688cellular_componentparallel fiber to Purkinje cell synapse
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B0099505biological_processregulation of presynaptic membrane potential
B0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C0000149molecular_functionSNARE binding
C0001540molecular_functionamyloid-beta binding
C0001919biological_processregulation of receptor recycling
C0004970molecular_functionglutamate-gated receptor activity
C0004971molecular_functionAMPA glutamate receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005234molecular_functionextracellularly glutamate-gated ion channel activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0007268biological_processchemical synaptic transmission
C0008021cellular_componentsynaptic vesicle
C0008092molecular_functioncytoskeletal protein binding
C0008328cellular_componentionotropic glutamate receptor complex
C0009986cellular_componentcell surface
C0010226biological_processresponse to lithium ion
C0014069cellular_componentpostsynaptic density
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0015277molecular_functionkainate selective glutamate receptor activity
C0016020cellular_componentmembrane
C0019722biological_processcalcium-mediated signaling
C0019865molecular_functionimmunoglobulin binding
C0019901molecular_functionprotein kinase binding
C0021987biological_processcerebral cortex development
C0022849molecular_functionglutamate-gated calcium ion channel activity
C0022890molecular_functioninorganic cation transmembrane transporter activity
C0030165molecular_functionPDZ domain binding
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030426cellular_componentgrowth cone
C0030672cellular_componentsynaptic vesicle membrane
C0031623biological_processreceptor internalization
C0032279cellular_componentasymmetric synapse
C0032281cellular_componentAMPA glutamate receptor complex
C0032590cellular_componentdendrite membrane
C0032839cellular_componentdendrite cytoplasm
C0032991cellular_componentprotein-containing complex
C0034220biological_processmonoatomic ion transmembrane transport
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035249biological_processsynaptic transmission, glutamatergic
C0035254molecular_functionglutamate receptor binding
C0035255molecular_functionionotropic glutamate receptor binding
C0036477cellular_componentsomatodendritic compartment
C0038023molecular_functionsignaling receptor activity
C0042734cellular_componentpresynaptic membrane
C0042802molecular_functionidentical protein binding
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043195cellular_componentterminal bouton
C0043197cellular_componentdendritic spine
C0043198cellular_componentdendritic shaft
C0043204cellular_componentperikaryon
C0043226cellular_componentorganelle
C0044326cellular_componentdendritic spine neck
C0044327cellular_componentdendritic spine head
C0044877molecular_functionprotein-containing complex binding
C0045184biological_processestablishment of protein localization
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0048787cellular_componentpresynaptic active zone membrane
C0050804biological_processmodulation of chemical synaptic transmission
C0050806biological_processpositive regulation of synaptic transmission
C0051262biological_processprotein tetramerization
C0051966biological_processregulation of synaptic transmission, glutamatergic
C0060078biological_processregulation of postsynaptic membrane potential
C0060079biological_processexcitatory postsynaptic potential
C0060992biological_processresponse to fungicide
C0097060cellular_componentsynaptic membrane
C0097110molecular_functionscaffold protein binding
C0098655biological_processmonoatomic cation transmembrane transport
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098793cellular_componentpresynapse
C0098839cellular_componentpostsynaptic density membrane
C0098978cellular_componentglutamatergic synapse
C0099094molecular_functionligand-gated monoatomic cation channel activity
C0099505biological_processregulation of presynaptic membrane potential
C0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C0099544cellular_componentperisynaptic space
C0106033cellular_componentspine synapse
C1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C1905430biological_processcellular response to glycine
C1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
D0001540molecular_functionamyloid-beta binding
D0001919biological_processregulation of receptor recycling
D0004970molecular_functionglutamate-gated receptor activity
D0004971molecular_functionAMPA glutamate receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0008328cellular_componentionotropic glutamate receptor complex
D0010226biological_processresponse to lithium ion
D0014069cellular_componentpostsynaptic density
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0019722biological_processcalcium-mediated signaling
D0022849molecular_functionglutamate-gated calcium ion channel activity
D0022890molecular_functioninorganic cation transmembrane transporter activity
D0030425cellular_componentdendrite
D0032279cellular_componentasymmetric synapse
D0032281cellular_componentAMPA glutamate receptor complex
D0032991cellular_componentprotein-containing complex
D0034220biological_processmonoatomic ion transmembrane transport
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035249biological_processsynaptic transmission, glutamatergic
D0038023molecular_functionsignaling receptor activity
D0042734cellular_componentpresynaptic membrane
D0043025cellular_componentneuronal cell body
D0043083cellular_componentsynaptic cleft
D0043195cellular_componentterminal bouton
D0043197cellular_componentdendritic spine
D0043198cellular_componentdendritic shaft
D0043204cellular_componentperikaryon
D0043226cellular_componentorganelle
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0048787cellular_componentpresynaptic active zone membrane
D0050804biological_processmodulation of chemical synaptic transmission
D0051289biological_processprotein homotetramerization
D0051290biological_processprotein heterotetramerization
D0060078biological_processregulation of postsynaptic membrane potential
D0060291biological_processlong-term synaptic potentiation
D0060992biological_processresponse to fungicide
D0098688cellular_componentparallel fiber to Purkinje cell synapse
D0098839cellular_componentpostsynaptic density membrane
D0098978cellular_componentglutamatergic synapse
D0099505biological_processregulation of presynaptic membrane potential
D0099507molecular_functionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D1904315molecular_functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTRANSMEM: Helical => ECO:0000250
ChainResidueDetails
BTYR525-VAL545
BLEU600-TYR620
DTYR525-VAL545
DLEU600-TYR620

site_idSWS_FT_FI2
Number of Residues164
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
BSER546-GLU574
BASP594-SER599
BGLU817-ILE866
DSER546-GLU574
DASP594-SER599
DGLU817-ILE866

site_idSWS_FT_FI3
Number of Residues30
DetailsINTRAMEM: Helical; Pore-forming => ECO:0000250
ChainResidueDetails
BPHE575-GLN590
DPHE575-GLN590

site_idSWS_FT_FI4
Number of Residues4
DetailsINTRAMEM: INTRAMEM => ECO:0000250
ChainResidueDetails
BGLN591-CYS593
DGLN591-CYS593

site_idSWS_FT_FI5
Number of Residues348
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
BTHR621-ASN795
DTHR621-ASN795

site_idSWS_FT_FI6
Number of Residues40
DetailsTRANSMEM: Helical; Name=M4 => ECO:0000250
ChainResidueDetails
BVAL796-ILE816
DVAL796-ILE816

site_idSWS_FT_FI7
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:19003990, ECO:0000269|PubMed:20199107, ECO:0007744|PDB:3DLN, ECO:0007744|PDB:3M3F, ECO:0007744|PDB:3M3K
ChainResidueDetails
BPRO480
DSER658
DTHR659
DGLU709
BTHR482
BARG487
BSER658
BTHR659
BGLU709
DPRO480
DTHR482
DARG487

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z2W9
ChainResidueDetails
BTYR849
BTYR859
DTYR849
DTYR859
CARG660
CLYS752

site_idSWS_FT_FI9
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:P23819
ChainResidueDetails
BCYS593
DCYS593

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q9Z2W9
ChainResidueDetails
BCYS819
DCYS819

site_idSWS_FT_FI11
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN35
BASN387
BASN394
DASN35
DASN387
DASN394

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317871, ECO:0007744|PubMed:24090084
ChainResidueDetails
BASN238
DASN238
ASER859
CSER839
CSER842
CSER859

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317871
ChainResidueDetails
BASN352
DASN352

site_idSWS_FT_FI14
Number of Residues4
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS589
ACYS815
CCYS589
CCYS815

site_idSWS_FT_FI15
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21317873
ChainResidueDetails
AASN235
CASN235

site_idSWS_FT_FI16
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19946266, ECO:0000269|PubMed:21317873, ECO:0000269|PubMed:25103405
ChainResidueDetails
AASN349
CASN349

site_idSWS_FT_FI17
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN385
AASN392
CASN385
CASN392

222624

PDB entries from 2024-07-17

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